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Gene

ERBB4

erb-b2 receptor tyrosine kinase 4

Summary

Cytogenetic location
2q34
Coordinates
Chromosome 2: 211,375,717–212,538,802 (GRCh38)
Exons
28 exons across 1,163.1 kb
Protein
1,308 amino acids
Also known as
ALS19, HER4
MANE Select transcript
ENST00000342788.9NM_005235.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Amyotrophic Lateral Sclerosis (ALS)

    • Amyotrophic Lateral Sclerosis

      A neurodegenerative disorder of upper and lower motor neurons, occurring in sporadic and familial forms.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Tofersen (Qalsody, FDA 2023) for SOD1-ALS; ASO trials for C9orf72 and FUS; riluzole; edaravone; AMX0035 (sodium phenylbutyrate-taurursodiol); multidisciplinary ALS clinic care; respiratory support; genetic counseling for family members

Broader groupings

How ERBB4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where ERBB4 sits. ERBB4 and 6 genes near it on chromosome 2, from 210,212,631 to 213,701,888.Chromosome 22q34p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3210.5 Mb211 Mb211.5 Mb212 Mb212.5 Mb213 Mb213.5 MbACADL: 210,187,000–210,225,447, reverse strandACADLMYL1: 210,290,145–210,315,180, reverse strandMYL1LANCL1: 210,424,562–210,477,652, reverse strandLANCL1CPS1: 210,477,641–210,679,109, forward strandCPS1ERBB4: 211,375,717–212,538,802, reverse strandERBB4IKZF2: 212,999,691–213,152,427, reverse strandIKZF2SPAG16: 213,284,360–214,410,501, forward strandSPAG16Diagram of ERBB4: 28 exons on the reverse strand of chromosome 2Exon 28: 1 known disease-causing siteExon 27: 1 known disease-causing siteExon 28: 211,375,717–211,384,060, 8,344 basesExon 27: 211,386,853–211,387,150, 298 basesExon 26: 211,387,945–211,387,992, 48 basesExon 25: 211,420,441–211,420,611, 171 basesExon 24: 211,422,007–211,422,104, 98 basesExon 23: 211,424,155–211,424,301, 147 basesExon 22: 211,428,408–211,428,483, 76 basesExon 21: 211,430,945–211,431,100, 156 basesExon 20: 211,561,903–211,562,088, 186 basesExon 19: 211,619,177–211,619,275, 99 basesExon 18: 211,623,922–211,624,044, 123 basesExon 17: 211,630,462–211,630,594, 133 basesExon 16: 211,657,754–211,657,828, 75 basesExon 15: 211,665,323–211,665,477, 155 basesExon 14: 211,673,164–211,673,257, 94 basesExon 13: 211,679,052–211,679,184, 133 basesExon 12: 211,701,967–211,702,166, 200 basesExon 11: 211,704,104–211,704,194, 91 basesExon 10: 211,705,318–211,705,391, 74 basesExon 9: 211,712,050–211,712,176, 127 basesExon 8: 211,713,535–211,713,648, 114 basesExon 7: 211,722,393–211,722,534, 142 basesExon 6: 211,725,076–211,725,194, 119 basesExon 5: 211,750,639–211,750,704, 66 basesExon 4: 211,788,025–211,788,159, 135 basesExon 3: 211,947,430–211,947,616, 187 basesExon 2: 212,124,752–212,124,903, 152 basesExon 1: 212,538,449–212,538,802, 354 bases2825201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.1 kb of the gene's 1,163.1 kb; 3,927 of those bases code for the protein.

How a genome test reads ERBB4

3

positions in ERBB4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1,163.1 kb of ERBB4, introns included, not only the 12.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ERBB4 gene: erb-b2 receptor tyrosine kinase 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/erbb4

Vancouver

Dante Labs. ERBB4 gene: erb-b2 receptor tyrosine kinase 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/erbb4

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