Gene
TEK
TEK receptor tyrosine kinase
- HGNC 11724(opens in a new tab)
- Ensembl gene ENSG00000120156(opens in a new tab)
- NCBI Gene 7010(opens in a new tab)
Summary
- Cytogenetic location
- 9p21.2
- Coordinates
- Chromosome 9: 27,109,225–27,230,174 (GRCh38)
- Exons
- 23 exons across 121 kb
- Protein
- 1,124 amino acids
- Inheritance
- Autosomal dominant
- Also known as
- TIE2, TIE-2, VMCM1, CD202b
- Previous symbols
- VMCM
- MANE Select transcript
- ENST00000380036.10NM_000459.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
Glaucoma
Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
- ClinGen rates the link definitive
- 4 GenCC submitters rate it definitive or strong
What knowing changes
IOP-lowering drops (prostaglandin analogs, beta-blockers); selective laser trabeculoplasty; MIGS surgery; trabeculotomy/goniotomy for congenital glaucoma; cascade family genetic testing; annual IOP monitoring for carriers
Hereditary Vascular Malformations
- Multiple Cutaneous and Mucosal Venous MalformationsAutosomal dominant
A condition caused by changes in TEK that causes multiple small bluish venous malformations in the skin and lining of the mouth or gut.
- 4 GenCC submitters rate it definitive or strong
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How TEK is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.7 kb of the gene's 121 kb; 3,375 of those bases code for the protein.
How a genome test reads TEK
29
positions in TEK where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 121 kb of TEK, introns included, not only the 4.7 kb of exons.
Traits linked to TEK
The Human Phenotype Ontology lists these as features of the rare conditions TEK can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TEK gene: TEK receptor tyrosine kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/tek
Dante Labs. TEK gene: TEK receptor tyrosine kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tek
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