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Gene

OVOL2

ovo like zinc finger 2

Summary

Cytogenetic location
20p11.23
Coordinates
Chromosome 20: 18,024,163–18,057,916 (GRCh38)
Exons
4 exons across 33.8 kb
Protein
275 amino acids
Also known as
bA504H3.3, HOVO2, CHED
Previous symbols
ZNF339, CHED1
MANE Select transcript
ENST00000278780.7NM_021220.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Corneal Dystrophies

    • Corneal Dystrophy

      A group of inherited conditions affecting one or more layers of the cornea, including Fuchs endothelial dystrophy (often linked to a TCF4 repeat expansion), TGFBI-related granular and lattice dystrophies, and rarer types caused by genes such as SLC4A11, COL8A2, ZEB1 and CHST6.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Carriers of TGFBI variants are generally advised to avoid laser refractive surgery (LASIK or PRK), which can make deposits worse; corneal transplant can restore vision in advanced disease.

How OVOL2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 20, with a bracket where OVOL2 sits. OVOL2 and 13 genes near it on chromosome 20, from 17,541,040 to 18,541,039.Chromosome 2020p11.23p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3317.6 Mb17.8 Mb18 Mb18.2 Mb18.4 MbBFSP1: 17,493,905–17,569,220, reverse strandBFSP1DSTN: 17,569,152–17,609,919, forward strandDSTNRRBP1: 17,613,678–17,682,295, reverse strandRRBP1BANF2: 17,693,672–17,735,873, forward strandBANF2SNX5: 17,941,597–17,969,022, reverse strandSNX5MGME1: 17,968,093–17,991,136, forward strandMGME1OVOL2: 18,024,163–18,057,916, reverse strandOVOL2KAT14: 18,137,228–18,188,844, forward strandKAT14PET117: 18,137,832–18,143,290, forward strandPET117ZNF133: 18,288,265–18,316,996, forward strandZNF133DZANK1: 18,383,361–18,467,332, reverse strandDZANK1POLR3F: 18,466,878–18,484,648, forward strandPOLR3FRBBP9: 18,486,540–18,497,260, reverse strandRBBP9SEC23B: 18,507,520–18,561,422, forward strandSEC23BDiagram of OVOL2: 4 exons on the reverse strand of chromosome 20Exon 4: 18,024,163–18,024,952, 790 basesExon 3: 18,041,534–18,041,723, 190 basesExon 2: 18,056,657–18,056,877, 221 basesExon 1: 18,057,535–18,057,916, 382 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 33.8 kb; 828 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). OVOL2 gene: ovo like zinc finger 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/ovol2

Vancouver

Dante Labs. OVOL2 gene: ovo like zinc finger 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ovol2

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