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Gene

EXOSC2

exosome component 2

Summary

Cytogenetic location
9q34.12
Coordinates
Chromosome 9: 130,693,780–130,704,892 (GRCh38)
Exons
9 exons across 11.1 kb
Protein
293 amino acids
Also known as
hRrp4p, Rrp4p, RRP4, p7
MANE Select transcript
ENST00000372358.10NM_014285.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads EXOSC2 yet. The test sequences your whole genome, so your data includes it all the same.

How EXOSC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where EXOSC2 sits. EXOSC2 and 12 genes near it on chromosome 9, from 130,199,336 to 131,199,335.Chromosome 99q34.12p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3130.2 Mb130.4 Mb130.6 Mb130.8 Mb131 MbNCS1: 130,172,315–130,237,737, forward strandNCS1HMCN2: 130,265,746–130,434,123, forward strandHMCN2ASS1: 130,443,282–130,502,361, forward strandASS1FUBP3: 130,578,965–130,638,354, forward strandFUBP3PRDM12: 130,664,594–130,682,986, forward strandPRDM12EXOSC2: 130,693,780–130,704,892, forward strandEXOSC2ABL1: 130,713,043–130,887,675, forward strandABL1: 130,713,626–130,713,724, forward strandQRFP: 130,892,707–130,896,812, reverse strandQRFPFIBCD1: 130,900,194–130,941,232, reverse strandFIBCD1LAMC3: 131,008,878–131,094,473, forward strandLAMC3AIF1L: 131,096,446–131,123,243, forward strandAIF1LNUP214: 131,124,868–131,234,667, forward strandNUP214Diagram of EXOSC2: 9 exons on the forward strand of chromosome 9Exon 1: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 1: 130,693,780–130,693,913, 134 basesExon 2: 130,695,492–130,695,593, 102 basesExon 3: 130,697,582–130,697,627, 46 basesExon 4: 130,698,162–130,698,251, 90 basesExon 5: 130,699,329–130,699,394, 66 basesExon 6: 130,700,867–130,700,935, 69 basesExon 7: 130,702,134–130,702,310, 177 basesExon 8: 130,703,053–130,703,181, 129 basesExon 9: 130,703,694–130,704,892, 1,199 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 11.1 kb; 882 of those bases code for the protein.

How a genome test reads EXOSC2

6

positions in EXOSC2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.1 kb of EXOSC2, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). EXOSC2 gene: exosome component 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/exosc2

Vancouver

Dante Labs. EXOSC2 gene: exosome component 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/exosc2

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