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Gene

ADH5

alcohol dehydrogenase 5 (class III), chi polypeptide

Summary

Cytogenetic location
4q23
Coordinates
Chromosome 4: 99,070,978–99,088,788 (GRCh38)
Exons
9 exons across 17.8 kb
Protein
374 amino acids
Also known as
ADH-3, ADHX, GSNOR
Previous symbols
FDH
MANE Select transcript
ENST00000296412.14NM_000671.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Rare Inherited Bone Marrow Failure Syndromes

    • Bone Marrow Failure Syndrome

      A group of rare conditions linked to genes such as DNAJC21, MYSM1 and SRP72, and to combined ADH5 and ALDH2 deficiency (AMED syndrome), causing low blood counts, sometimes with developmental or other features.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A diagnosis informs the choice of related stem cell donors and transplant preparation, and supports monitoring for myelodysplastic syndrome and leukaemia.

How ADH5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where ADH5 sits. ADH5 and 12 genes near it on chromosome 4, from 98,579,883 to 99,579,882.Chromosome 44q23p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.298.6 Mb98.8 Mb99 Mb99.2 Mb99.4 MbTSPAN5: 98,470,365–98,658,713, reverse strandTSPAN5EIF4E: 98,876,654–98,929,925, reverse strandEIF4EMETAP1: 98,995,359–99,065,059, forward strandMETAP1ADH5: 99,070,978–99,088,788, reverse strandADH5ADH4: 99,123,502–99,157,792, reverse strandADH4ADH6: 99,202,424–99,219,537, reverse strandADH6ADH1A: 99,275,958–99,291,552, reverse strandADH1AADH1B: 99,304,971–99,321,659, reverse strandADH1BADH1C: 99,336,093–99,382,896, reverse strandADH1CADH7: 99,412,261–99,435,698, reverse strandADH7C4orf17: 99,511,012–99,542,303, forward strandC4orf17TRMT10A: 99,546,700–99,564,070, reverse strandTRMT10AMTTP: 99,564,081–99,623,997, forward strandMTTPDiagram of ADH5: 9 exons on the reverse strand of chromosome 4Exon 7: 1 known disease-causing siteExon 9: 99,070,978–99,072,441, 1,464 basesExon 8: 99,072,573–99,072,711, 139 basesExon 7: 99,074,914–99,075,049, 136 basesExon 6: 99,076,292–99,076,552, 261 basesExon 5: 99,076,704–99,076,923, 220 basesExon 4: 99,081,365–99,081,452, 88 basesExon 3: 99,081,975–99,082,116, 142 basesExon 2: 99,085,115–99,085,216, 102 basesExon 1: 99,088,689–99,088,788, 100 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 17.8 kb; 1,125 of those bases code for the protein.

How a genome test reads ADH5

2

positions in ADH5 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (50%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 17.8 kb of ADH5, introns included, not only the 2.7 kb of exons.

Genes linked to the same conditions

Traits linked to ADH5

The Human Phenotype Ontology lists these as features of the rare conditions ADH5 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADH5 gene: alcohol dehydrogenase 5 (class III), chi polypeptide. Retrieved 17 October 2026, from https://dantelabs.com/genes/adh5

Vancouver

Dante Labs. ADH5 gene: alcohol dehydrogenase 5 (class III), chi polypeptide [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/adh5

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