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Gene

TBXAS1

thromboxane A synthase 1

Summary

Cytogenetic location
7q34
Coordinates
Chromosome 7: 139,829,264–140,020,293 (GRCh38)
Exons
13 exons across 191 kb
Protein
533 amino acids
Also known as
CYP5, CYP5A1, THAS, TXS, TXAS, TS
MANE Select transcript
ENST00000448866.7NM_001061.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TBXAS1 yet. The test sequences your whole genome, so your data includes it all the same.

How TBXAS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where TBXAS1 sits. TBXAS1 and 8 genes near it on chromosome 7, from 139,424,779 to 140,424,778.Chromosome 77q34p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3139.6 Mb139.8 Mb140 Mb140.2 Mb140.4 MbLUC7L2: 139,340,359–139,425,496, forward strandLUC7L2KLRG2: 139,450,625–139,483,719, reverse strandKLRG2CLEC2L: 139,523,668–139,544,985, forward strandCLEC2LHIPK2: 139,561,570–139,778,016, reverse strandHIPK2TBXAS1: 139,829,264–140,020,293, forward strandTBXAS1PARP12: 140,023,742–140,063,344, reverse strandPARP12KDM7A: 140,084,746–140,177,678, reverse strandKDM7ASLC37A3: 140,293,693–140,404,433, reverse strandSLC37A3RAB19: 140,404,043–140,427,974, forward strandRAB19Diagram of TBXAS1: 13 exons on the forward strand of chromosome 7Exon 1: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 1: 139,829,264–139,829,479, 216 basesExon 2: 139,872,235–139,872,328, 94 basesExon 3: 139,875,585–139,875,637, 53 basesExon 4: 139,911,225–139,911,321, 97 basesExon 5: 139,936,191–139,936,307, 117 basesExon 6: 139,953,368–139,953,456, 89 basesExon 7: 139,955,459–139,955,607, 149 basesExon 8: 139,957,634–139,957,764, 131 basesExon 9: 139,961,919–139,962,233, 315 basesExon 10: 140,007,091–140,007,182, 92 basesExon 11: 140,015,723–140,015,860, 138 basesExon 12: 140,017,671–140,017,833, 163 basesExon 13: 140,020,025–140,020,293, 269 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 191 kb; 1,602 of those bases code for the protein.

How a genome test reads TBXAS1

9

positions in TBXAS1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 191 kb of TBXAS1, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TBXAS1 gene: thromboxane A synthase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/tbxas1

Vancouver

Dante Labs. TBXAS1 gene: thromboxane A synthase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tbxas1

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