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Gene

SRP72

signal recognition particle 72

Summary

Cytogenetic location
4q12
Coordinates
Chromosome 4: 56,467,617–56,503,681 (GRCh38)
Exons
19 exons across 36.1 kb
Protein
671 amino acids
MANE Select transcript
ENST00000642900.1NM_006947.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Inherited Bone Marrow Failure Syndromes

    • Bone Marrow Failure Syndrome

      A group of rare conditions linked to genes such as DNAJC21, MYSM1 and SRP72, and to combined ADH5 and ALDH2 deficiency (AMED syndrome), causing low blood counts, sometimes with developmental or other features.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A diagnosis informs the choice of related stem cell donors and transplant preparation, and supports monitoring for myelodysplastic syndrome and leukaemia.

How SRP72 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where SRP72 sits. SRP72 and 12 genes near it on chromosome 4, from 55,985,649 to 56,985,648.Chromosome 44q12p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.256 Mb56.2 Mb56.4 Mb56.6 Mb56.8 MbCEP135: 55,948,819–56,033,361, forward strandCEP135CRACD: 56,049,091–56,330,609, forward strandCRACDAASDH: 56,337,482–56,387,523, reverse strandAASDHPPAT: 56,393,362–56,436,038, reverse strandPPATPAICS: 56,435,058–56,464,578, forward strandPAICSSRP72: 56,467,617–56,503,681, forward strandSRP72ARL9: 56,505,209–56,524,959, forward strandARL9SPMAP2L: 56,530,601–56,603,556, forward strandSPMAP2LHOPX: 56,647,195–56,681,877, reverse strandHOPXSPINK2: 56,809,857–56,821,869, reverse strandSPINK2REST: 56,907,853–56,967,011, forward strandRESTNOA1: 56,961,620–56,977,625, reverse strandNOA1POLR2B: 56,977,711–57,031,158, forward strandPOLR2BDiagram of SRP72: 19 exons on the forward strand of chromosome 4Exon 1: 56,467,617–56,467,744, 128 basesExon 2: 56,469,653–56,469,773, 121 basesExon 3: 56,471,720–56,471,843, 124 basesExon 4: 56,474,054–56,474,197, 144 basesExon 5: 56,474,280–56,474,391, 112 basesExon 6: 56,476,671–56,476,702, 32 basesExon 7: 56,478,379–56,478,503, 125 basesExon 8: 56,478,592–56,478,649, 58 basesExon 9: 56,483,139–56,483,270, 132 basesExon 10: 56,484,736–56,484,864, 129 basesExon 11: 56,486,325–56,486,397, 73 basesExon 12: 56,487,949–56,488,013, 65 basesExon 13: 56,489,388–56,489,483, 96 basesExon 14: 56,490,333–56,490,436, 104 basesExon 15: 56,490,568–56,490,645, 78 basesExon 16: 56,491,431–56,491,568, 138 basesExon 17: 56,495,357–56,495,394, 38 basesExon 18: 56,500,536–56,500,695, 160 basesExon 19: 56,501,684–56,503,681, 1,998 bases124681012141618195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 36.1 kb; 2,016 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SRP72 gene: signal recognition particle 72. Retrieved 17 October 2026, from https://dantelabs.com/genes/srp72

Vancouver

Dante Labs. SRP72 gene: signal recognition particle 72 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/srp72

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