Skip to content
Use your HSA or FSA funds

Gene

STN1

STN1 subunit of CST complex

Summary

Cytogenetic location
10q24.33
Coordinates
Chromosome 10: 103,877,569–103,918,184 (GRCh38)
Exons
10 exons across 40.6 kb
Protein
368 amino acids
Inheritance
Autosomal recessive
Also known as
FLJ22559, bA541N10.2
Previous symbols
OBFC1
MANE Select transcript
ENST00000224950.8NM_024928.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Dyskeratosis Congenita

    • Telomere syndromes

      Disorders of short telomeres caused by variants in telomere-maintenance genes such as TERT, TERC, RTEL1 and PARN, which can cause bone marrow failure, lung fibrosis and liver disease even without classic skin signs.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Monitoring of blood counts, lungs and liver is advised, and the diagnosis informs donor selection and treatment choices for stem cell transplantation.

  • Vitreoretinopathy

    • Coats Plus SyndromeAutosomal recessive

      Coats plus syndrome is a pleiotropic multisystem disorder characterized by retinal telangiectasia and exudates, intracranial calcification with leukoencephalopathy and brain cysts, osteopenia with predisposition to fractures, bone marrow suppression, gastrointestinal bleeding and portal hypertension. It is transmitted as an autosomal recessive disease.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How STN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where STN1 sits. STN1 and 14 genes near it on chromosome 10, from 103,397,877 to 104,397,876.Chromosome 1010q24.33p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3103.4 Mb103.6 Mb103.8 Mb104 Mb104.2 MbPDCD11: 103,396,602–103,446,297, forward strandPDCD11CALHM2: 103,446,777–103,452,780, reverse strandCALHM2CALHM1: 103,453,240–103,458,900, reverse strandCALHM1CALHM3: 103,472,804–103,479,240, reverse strandCALHM3NEURL1: 103,493,592–103,595,168, forward strandNEURL1SH3PXD2A: 103,594,027–103,855,773, reverse strandSH3PXD2ASTN1: 103,877,569–103,918,184, reverse strandSTN1SLK: 103,966,916–104,029,242, forward strandSLKCOL17A1: 104,030,753–104,086,410, reverse strandCOL17A1SFR1: 104,122,058–104,126,385, forward strandSFR1CFAP43: 104,129,888–104,232,364, reverse strandCFAP43GSTO1: 104,235,356–104,267,604, forward strandGSTO1GSTO2: 104,268,873–104,304,950, forward strandGSTO2ITPRIP: 104,308,501–104,338,812, reverse strandITPRIPCFAP58: 104,353,758–104,455,153, forward strandCFAP58Diagram of STN1: 10 exons on the reverse strand of chromosome 10Exon 2: 1 known disease-causing siteExon 10: 103,877,569–103,882,841, 5,273 basesExon 9: 103,889,072–103,889,144, 73 basesExon 8: 103,892,130–103,892,252, 123 basesExon 7: 103,897,548–103,897,719, 172 basesExon 6: 103,898,877–103,899,000, 124 basesExon 5: 103,900,062–103,900,223, 162 basesExon 4: 103,905,091–103,905,156, 66 basesExon 3: 103,910,527–103,910,622, 96 basesExon 2: 103,917,462–103,917,656, 195 basesExon 1: 103,918,100–103,918,184, 85 bases10515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.4 kb of the gene's 40.6 kb; 1,107 of those bases code for the protein.

How a genome test reads STN1

1

position in STN1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 40.6 kb of STN1, introns included, not only the 6.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). STN1 gene: STN1 subunit of CST complex. Retrieved 16 October 2026, from https://dantelabs.com/genes/stn1

Vancouver

Dante Labs. STN1 gene: STN1 subunit of CST complex [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/stn1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test