Traits

Traits linked to FGF8

fibroblast growth factor 8

The Human Phenotype Ontology links 180 traits to FGF8, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Hvor ofte den forekommer
Abnormal central motor function	Ofte (30–79 %)
Abnormal corpus callosum morphology	Ofte (30–79 %)
Abnormal morphology of the olfactory bulb	Ofte (30–79 %)
Abnormal shape of brainstem	Ofte (30–79 %)
Abnormal shape of midbrain	Ofte (30–79 %)
Abnormality of the autonomic nervous system	Ofte (30–79 %)
Absent speech development	Ofte (30–79 %)
Anxiety	Ofte (30–79 %)
Aplasia of the falx cerebri	Ofte (30–79 %)
Attention deficit	Ofte (30–79 %)
Behavioral abnormality	Ofte (30–79 %)
Communication delay	Ofte (30–79 %)
Depression	Ofte (30–79 %)
Epilepsy	Ofte (30–79 %)
Impulsivity	Ofte (30–79 %)
Inability to walk	Ofte (30–79 %)
Intellectual disability	Ofte (30–79 %)
Irritability	Ofte (30–79 %)
Lack of feeling, emotion, interest	Ofte (30–79 %)
Lethargy	Ofte (30–79 %)
Limb dystonia	Ofte (30–79 %)
Neural tube defect	Ofte (30–79 %)
Oromotor apraxia	Ofte (30–79 %)
Poor speech	Ofte (30–79 %)
Short attention span	Ofte (30–79 %)
Sleep-wake cycle disturbance	Ofte (30–79 %)
Specific learning disability	Ofte (30–79 %)
Abnormal gait	Noen ganger (5–29 %)
Abnormal septum pellucidum morphology	Noen ganger (5–29 %)
Agenesis of corpus callosum	Noen ganger (5–29 %)
Ataxia	Noen ganger (5–29 %)
Difficulty articulating speech	Noen ganger (5–29 %)
Enlarged brain	Noen ganger (5–29 %)
Hand mirror movements	Noen ganger (5–29 %)
Holoprosencephaly	Noen ganger (5–29 %)
Hypoplasia of the pons	Noen ganger (5–29 %)
Leg paralysis	Noen ganger (5–29 %)
Perisylvian polymicrogyria	Noen ganger (5–29 %)
Rhombencephalosynapsis	Noen ganger (5–29 %)
Too much cerebrospinal fluid in the brain	Noen ganger (5–29 %)
Tremor	Noen ganger (5–29 %)

Abnormality of head or neck

Trait	Hvor ofte den forekommer
Blockage of the rear opening of the nasal cavity	Svært ofte (80–99 %)
Hyposmia	Svært ofte (80–99 %)
Lost smell	Svært ofte (80–99 %)
Midnasal stenosis	Svært ofte (80–99 %)
Only one upper front tooth	Svært ofte (80–99 %)
Abnormally small head	Ofte (30–79 %)
Bifid uvula	Ofte (30–79 %)
Central cleft upper lip	Ofte (30–79 %)
Cleft palate	Ofte (30–79 %)
Flat nose	Ofte (30–79 %)
High palate	Ofte (30–79 %)
Narrow nasal bridge	Ofte (30–79 %)
Short philtrum	Ofte (30–79 %)
Tented mouth	Ofte (30–79 %)
Abnormal dentition	Noen ganger (5–29 %)
Big calvaria	Noen ganger (5–29 %)
Cleft lip	Noen ganger (5–29 %)
Cleft of the mouth	Noen ganger (5–29 %)
Decreased number of teeth	Noen ganger (5–29 %)
Depressed nasal bridge	Noen ganger (5–29 %)
Frontoethmoidal encephalocele	Noen ganger (5–29 %)
Mono nostril	Noen ganger (5–29 %)
Nasal tip, upturned	Noen ganger (5–29 %)
Proboscis	Noen ganger (5–29 %)
Short nose	Noen ganger (5–29 %)

Abnormality of the genitourinary system

Trait	Hvor ofte den forekommer
Decreased testicular size	Alltid
Primary amenorrhea	Alltid
Short penis	Alltid
Abnormal erection	Svært ofte (80–99 %)
Absent sperm in semen	Svært ofte (80–99 %)
Decreased fertility	Svært ofte (80–99 %)
Difficulty getting a full erection	Svært ofte (80–99 %)
Increased female sex drive	Svært ofte (80–99 %)
Non-obstructive azoospermia	Svært ofte (80–99 %)
Underdeveloped penis	Svært ofte (80–99 %)
Undescended testes	Svært ofte (80–99 %)
Previous menstrual periods stop	Ofte (30–79 %)
Small uterus	Ofte (30–79 %)
Underdeveloped ovary	Ofte (30–79 %)
Abnormal morphology of female internal genitalia	Noen ganger (5–29 %)
Abnormality of the genitourinary system	Noen ganger (5–29 %)
Absent kidney	Noen ganger (5–29 %)
Ambiguous external genitalia	Noen ganger (5–29 %)
Dyspareunia	Noen ganger (5–29 %)
Infertility	Noen ganger (5–29 %)

Abnormality of the musculoskeletal system

Trait	Hvor ofte den forekommer
Delayed bone maturation	Svært ofte (80–99 %)
Abnormal vertebral morphology	Ofte (30–79 %)
Abnormality of the ribs	Ofte (30–79 %)
Decreased muscle tone in infant	Ofte (30–79 %)
Generalized decreased muscle tone	Ofte (30–79 %)
Involuntary muscle stiffness, contraction, or spasm	Ofte (30–79 %)
Low solidness and mass of the bones	Ofte (30–79 %)
Osteopenia	Ofte (30–79 %)
Osteoporosis	Ofte (30–79 %)
Abnormal skeletal development	Noen ganger (5–29 %)
Abnormality of the skeletal system	Noen ganger (5–29 %)
EMG: myopathic abnormalities	Noen ganger (5–29 %)
Flexed joint that cannot be straightened	Noen ganger (5–29 %)
Hypermobility of all joints	Noen ganger (5–29 %)
Low muscle tone	Noen ganger (5–29 %)
Low muscle tone in trunk	Noen ganger (5–29 %)
Muscle weakness	Noen ganger (5–29 %)
Permanent flexion of the finger or toe	Noen ganger (5–29 %)
Recurrent fractures	Noen ganger (5–29 %)
Scoliosis	Noen ganger (5–29 %)

Abnormality of the endocrine system

Trait	Hvor ofte den forekommer
Hypogonadotropic hypogonadism	Alltid
Absence of pubertal development	Svært ofte (80–99 %)
Absence of secondary sex characteristics	Svært ofte (80–99 %)
Anterior hypopituitarism	Svært ofte (80–99 %)
Decreased function of male gonad	Svært ofte (80–99 %)
Decreased serum testosterone level	Svært ofte (80–99 %)
Delayed puberty	Svært ofte (80–99 %)
Female hypogonadism	Svært ofte (80–99 %)
Gonadotropin-releasing hormone deficiency	Svært ofte (80–99 %)
Abnormal hypothalamus physiology	Ofte (30–79 %)
Abnormality of the endocrine system	Ofte (30–79 %)
Central diabetes insipidus	Ofte (30–79 %)
Diabetes insipidus	Ofte (30–79 %)
Early onset of puberty	Ofte (30–79 %)
Central hypothyroidism	Noen ganger (5–29 %)
Decreased response to growth hormone stimulation test	Noen ganger (5–29 %)
Panhypopituitarism	Noen ganger (5–29 %)
Underactive thyroid	Noen ganger (5–29 %)
Small pituitary gland	Ikke registrert

Abnormality of the eye

Trait	Hvor ofte den forekommer
Abnormality of the eye	Svært ofte (80–99 %)
Abnormally close eyes	Svært ofte (80–99 %)
Cerebral visual impairment	Ofte (30–79 %)
Abnormal color vision	Noen ganger (5–29 %)
Cat eye	Noen ganger (5–29 %)
Cross-eyed	Noen ganger (5–29 %)
Cyclops eye	Noen ganger (5–29 %)
Drooping upper eyelid	Noen ganger (5–29 %)
Involuntary, rapid, rhythmic eye movements	Noen ganger (5–29 %)
Visual impairment	Noen ganger (5–29 %)
Wide-set eyes	Noen ganger (5–29 %)

Abnormality of the digestive system

Trait	Hvor ofte den forekommer
Feeding difficulties	Svært ofte (80–99 %)
Poor suck	Svært ofte (80–99 %)
Acid reflux	Ofte (30–79 %)
Constipation	Ofte (30–79 %)
Poor swallowing	Ofte (30–79 %)
Vomiting	Ofte (30–79 %)
Abnormal shape of the digestive system	Noen ganger (5–29 %)
Absence or narrowing of first part of small bowel	Noen ganger (5–29 %)
Anteriorly placed anus	Noen ganger (5–29 %)
Gastrostomy tube feeding in infancy	Noen ganger (5–29 %)

Growth abnormality

Trait	Hvor ofte den forekommer
Eunuchoid habitus	Svært ofte (80–99 %)
Faltering weight	Svært ofte (80–99 %)
Growth delay	Svært ofte (80–99 %)
Short stature	Svært ofte (80–99 %)
Abnormality of body height	Ofte (30–79 %)
Prenatal growth deficiency	Ofte (30–79 %)
Obesity	Noen ganger (5–29 %)

Abnormality of the cardiovascular system

Trait	Hvor ofte den forekommer
Abnormal cardiovascular system morphology	Noen ganger (5–29 %)
Abnormal heart rate variability	Noen ganger (5–29 %)
Abnormality of the heart	Noen ganger (5–29 %)
Narrowing of aorta	Noen ganger (5–29 %)
Strawberry mark	Noen ganger (5–29 %)
Tetralogy of Fallot	Noen ganger (5–29 %)

Abnormality of limbs

Trait	Hvor ofte den forekommer
Abnormality of limbs	Noen ganger (5–29 %)
Dropped arches	Noen ganger (5–29 %)
High-arched foot	Noen ganger (5–29 %)
Hip dislocation	Noen ganger (5–29 %)

Abnormality of the integument

Trait	Hvor ofte den forekommer
Limited armpit hair	Alltid
Sparse pubic hair	Alltid
Sparse body hair	Svært ofte (80–99 %)
Ichthyosis	Noen ganger (5–29 %)

Abnormality of the breast

Trait	Hvor ofte den forekommer
Underdeveloped breasts	Svært ofte (80–99 %)
Wide-spaced nipples	Svært ofte (80–99 %)
Enlarged male breast	Ofte (30–79 %)

Abnormality of the respiratory system

Trait	Hvor ofte den forekommer
Abnormal pattern of respiration	Ofte (30–79 %)
Central apnea	Ofte (30–79 %)
Chronic lung disease	Ofte (30–79 %)

Abnormality of the ear

Trait	Hvor ofte den forekommer
Sensorineural hearing impairment	Ofte (30–79 %)
Congenital sensorineural hearing impairment	Noen ganger (5–29 %)

Abnormality of the immune system

Trait	Hvor ofte den forekommer
Aspiration pneumonia	Ofte (30–79 %)
Asthma	Noen ganger (5–29 %)

Abnormality of prenatal development or birth

Trait	Hvor ofte den forekommer
Premature birth	Ofte (30–79 %)

Abnormality of the voice

Trait	Hvor ofte den forekommer
Abnormality of the voice	Svært ofte (80–99 %)

Laboratory abnormality

Trait	Hvor ofte den forekommer
Temperature instability	Ofte (30–79 %)

Hvor ofte dette forekommer hos personer med en av genets tilstander, oppgitt som den hyppigste forekomsten blant dem, slik Human Phenotype Ontology registrerer den. Disse sidene beskriver egenskaper og forskningen bak dem. De er ikke en diagnose, og om symptomer bør du spørre lege eller genetisk rådgiver.

Slik er informasjonen samlet

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FGF8 and how often each is seen. Find out more at hpo.jax.org.

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