Trait
Kidney damage
Clinical name: Nephropathy
A nonspecific term referring to disease or damage of the kidneys.
Summary
- Also called
- Kidney disease
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
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Get my Genome Test103 genes linked to Kidney damage
Changes in these genes cause rare conditions in which Kidney damage is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| IFT140intraflagellar transport 140 | Always | In 2 conditions |
| INPP5Einositol polyphosphate-5-phosphatase E | Always | In 2 conditions |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| PSKH1protein serine kinase H1 | Always | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Always | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Always | In 1 condition |
| CC2D2Acoiled-coil and C2 domain containing 2A | Very often (80–99%) | In 2 conditions |
| CEP290centrosomal protein 290 | Very often (80–99%) | In 1 condition |
| CLDN19claudin 19 | Very often (80–99%) | In 1 condition |
| FAM20AFAM20A golgi associated secretory pathway pseudokinase | Very often (80–99%) | In 1 condition |
| GON7GON7 subunit of KEOPS complex | Very often (80–99%) | In 1 condition |
| LAGE3L antigen family member 3 | Very often (80–99%) | In 1 condition |
| NPHP1nephrocystin 1 | Very often (80–99%) | In 1 condition |
| NUP107nucleoporin 107 | Very often (80–99%) | In 1 condition |
| NUP133nucleoporin 133 | Very often (80–99%) | In 1 condition |
| OSGEPO-sialoglycoprotein endopeptidase | Very often (80–99%) | In 1 condition |
| RPGRIP1LRPGRIP1 like | Very often (80–99%) | In 2 conditions |
| SAA1serum amyloid A1 | Very often (80–99%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Very often (80–99%) | In 1 condition |
| TMEM138transmembrane protein 138 | Very often (80–99%) | In 1 condition |
| TMEM216transmembrane protein 216 | Very often (80–99%) | In 1 condition |
| TMEM231transmembrane protein 231 | Very often (80–99%) | In 1 condition |
| TMEM237transmembrane protein 237 | Very often (80–99%) | In 2 conditions |
| TP53RKTP53 regulating kinase | Very often (80–99%) | In 1 condition |
| TPRKBTP53RK binding protein | Very often (80–99%) | In 1 condition |
| TTRtransthyretin | Very often (80–99%) | In 1 condition |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Very often (80–99%) | In 1 condition |
| WDR73WD repeat domain 73 | Very often (80–99%) | In 1 condition |
| WT1WT1 transcription factor | Very often (80–99%) | In 3 conditions |
| YRDCyrdC N6-threonylcarbamoyltransferase domain containing | Very often (80–99%) | In 1 condition |
| ZNF423zinc finger protein 423 | Very often (80–99%) | In 1 condition |
| CCND1cyclin D1 | Often (30–79%) | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Often (30–79%) | In 1 condition |
| COL4A5collagen type IV alpha 5 chain | Often (30–79%) | In 1 condition |
| COL4A6collagen type IV alpha 6 chain | Often (30–79%) | In 1 condition |
| GLAgalactosidase alpha | Often (30–79%) | In 1 condition |
| HPRT1hypoxanthine phosphoribosyltransferase 1 | Often (30–79%) | In 1 condition |
| MAFBMAF bZIP transcription factor B | Often (30–79%) | In 1 condition |
| MYH9myosin heavy chain 9 | Often (30–79%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Often (30–79%) | In 1 condition |
Show 63 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PRODHproline dehydrogenase 1 | Often (30–79%) | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Often (30–79%) | In 1 condition |
| SCNN1Bsodium channel epithelial 1 subunit beta | Often (30–79%) | In 1 condition |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Often (30–79%) | In 1 condition |
| TMEM67transmembrane protein 67 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Often (30–79%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Sometimes (5–29%) | In 1 condition |
| ADA2adenosine deaminase 2 | Sometimes (5–29%) | In 1 condition |
| APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Sometimes (5–29%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| CELcarboxyl ester lipase | Sometimes (5–29%) | In 1 condition |
| CEP120centrosomal protein 120 | Sometimes (5–29%) | In 1 condition |
| CPOXcoproporphyrinogen oxidase | Sometimes (5–29%) | In 1 condition |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Sometimes (5–29%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Sometimes (5–29%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Sometimes (5–29%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Sometimes (5–29%) | In 1 condition |
| FOXI1forkhead box I1 | Sometimes (5–29%) | In 1 condition |
| GCKglucokinase | Sometimes (5–29%) | In 1 condition |
| HIC1HIC ZBTB transcriptional repressor 1 | Sometimes (5–29%) | In 1 condition |
| HNF1AHNF1 homeobox A | Sometimes (5–29%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| IFT80intraflagellar transport 80 | Sometimes (5–29%) | In 1 condition |
| INSinsulin | Sometimes (5–29%) | In 1 condition |
| KCNJ10potassium inwardly rectifying channel subfamily J member 10 | Sometimes (5–29%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Sometimes (5–29%) | In 1 condition |
| KIAA0753KIAA0753 | Sometimes (5–29%) | In 1 condition |
| KLF11KLF transcription factor 11 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Sometimes (5–29%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Sometimes (5–29%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Sometimes (5–29%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Sometimes (5–29%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Sometimes (5–29%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Sometimes (5–29%) | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Sometimes (5–29%) | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Sometimes (5–29%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Sometimes (5–29%) | In 1 condition |
| NEUROD1neuronal differentiation 1 | Sometimes (5–29%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Sometimes (5–29%) | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Sometimes (5–29%) | In 1 condition |
| PAX4paired box 4 | Sometimes (5–29%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SLC26A4solute carrier family 26 member 4 | Sometimes (5–29%) | In 1 condition |
| SLC2A2solute carrier family 2 member 2 | Sometimes (5–29%) | In 1 condition |
| TTC21Btetratricopeptide repeat domain 21B | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 2 conditions |
| WDR19WD repeat domain 19 | Sometimes (5–29%) | In 1 condition |
| YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | Sometimes (5–29%) | In 1 condition |
| FGAfibrinogen alpha chain | Not recorded | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Not recorded | In 1 condition |
| PAX6paired box 6 | Not recorded | In 1 condition |
| PRDX1peroxiredoxin 1 | Not recorded | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Not recorded | In 1 condition |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Not recorded | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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