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Gene

DMRT1

doublesex and mab-3 related transcription factor 1

Summary

Cytogenetic location
9p24.3
Coordinates
Chromosome 9: 841,697–969,090 (GRCh38)
Exons
5 exons across 127.4 kb
Protein
373 amino acids
Also known as
DMT1, CT154
MANE Select transcript
ENST00000382276.8NM_021951.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • 46,XY Differences of Sex Development and Gonadal Dysgenesis

    • 46,XY differences of sex development

      Conditions in people with XY chromosomes in which gonadal or genital development is atypical, caused by variants in genes such as SRD5A2, HSD17B3, NR5A1, MAP3K1, DHH, WT1, CYP11A1 and LHCGR.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis informs hormone treatment, fertility counselling and, where dysgenetic gonads carry Y material, assessment of gonadal tumour risk.

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

How DMRT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 9, with a bracket where DMRT1 sits. DMRT1 and 4 genes near it on chromosome 9, from 405,394 to 1,405,393.Chromosome 99p24.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.30.6 Mb0.8 Mb1 Mb1.2 Mb1.4 MbDOCK8: 214,676–465,530, forward strandDOCK8KANK1: 470,289–746,105, forward strandKANK1DMRT1: 841,697–969,090, forward strandDMRT1DMRT3: 976,373–991,746, forward strandDMRT3DMRT2: 1,049,000–1,059,533, forward strandDMRT2Diagram of DMRT1: 5 exons on the forward strand of chromosome 9Exon 1: 841,697–842,192, 496 basesExon 2: 846,960–847,143, 184 basesExon 3: 893,912–894,195, 284 basesExon 4: 916,763–916,907, 145 basesExon 5: 967,985–969,090, 1,106 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 127.4 kb; 1,122 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DMRT1 gene: doublesex and mab-3 related transcription factor 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/dmrt1

Vancouver

Dante Labs. DMRT1 gene: doublesex and mab-3 related transcription factor 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dmrt1

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