Trait
Absent sperm in semen
Clinical name: Azoospermia
Absence of any measurable level of sperm,whereby spermatozoa cannot be observed even after centrifugation of the semen pellet.
Summary
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test144 genes linked to Absent sperm in semen
Changes in these genes cause rare conditions in which Absent sperm in semen is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| C14orf39chromosome 14 open reading frame 39 | Always | In 1 condition |
| DCAF17DDB1 and CUL4 associated factor 17 | Always | In 1 condition |
| DNAH9dynein axonemal heavy chain 9 | Always | In 1 condition |
| LHBluteinizing hormone subunit beta | Always | In 1 condition |
| M1APmeiosis 1 associated protein | Always | In 1 condition |
| SCP2sterol carrier protein 2 | Always | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Always | In 2 conditions |
| SOX9SRY-box transcription factor 9 | Always | In 2 conditions |
| STEAP3STEAP3 metalloreductase | Always | In 2 conditions |
| SYCP3synaptonemal complex protein 3 | Always | In 2 conditions |
| TEX11testis expressed 11 | Always | In 2 conditions |
| TEX14testis expressed 14, intercellular bridge forming factor | Always | In 2 conditions |
| XRCC2X-ray repair cross complementing 2 | Always | In 3 conditions |
| ZMYND15zinc finger MYND-type containing 15 | Always | In 2 conditions |
| CATIPciliogenesis associated TTC17 interacting protein | Very often (80–99%) | In 1 condition |
| CATSPER2cation channel sperm associated 2 | Very often (80–99%) | In 1 condition |
| CCDC34coiled-coil domain containing 34 | Very often (80–99%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Very often (80–99%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
| CT55cancer/testis antigen 55 | Very often (80–99%) | In 1 condition |
| DHX37DEAH-box helicase 37 | Very often (80–99%) | In 1 condition |
| DNAH10dynein axonemal heavy chain 10 | Very often (80–99%) | In 1 condition |
| DNHD1dynein heavy chain domain 1 | Very often (80–99%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Very often (80–99%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Very often (80–99%) | In 1 condition |
| FANCMFA complementation group M | Very often (80–99%) | In 2 conditions |
| FBXO43F-box protein 43 | Very often (80–99%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Very often (80–99%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Very often (80–99%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 1 condition |
| GATA4GATA binding protein 4 | Very often (80–99%) | In 1 condition |
| GCNAgerm cell nuclear acidic peptidase | Very often (80–99%) | In 2 conditions |
| GNRH1gonadotropin releasing hormone 1 | Very often (80–99%) | In 1 condition |
| GNRHRgonadotropin releasing hormone receptor | Very often (80–99%) | In 1 condition |
| HNF1BHNF1 homeobox B | Very often (80–99%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Very often (80–99%) | In 1 condition |
| KISS1KiSS-1 metastasis suppressor | Very often (80–99%) | In 1 condition |
| KISS1RKISS1 receptor | Very often (80–99%) | In 2 conditions |
| KLHL10kelch like family member 10 | Very often (80–99%) | In 1 condition |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Very often (80–99%) | In 1 condition |
Show 104 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MEIOBmeiosis specific with OB-fold | Very often (80–99%) | In 1 condition |
| MOV10L1Mov10 like RNA helicase 1 | Very often (80–99%) | In 1 condition |
| MSH5mutS homolog 5 | Very often (80–99%) | In 1 condition |
| NANOS1nanos C2HC-type zinc finger 1 | Very often (80–99%) | In 2 conditions |
| NHLH2nescient helix-loop-helix 2 | Very often (80–99%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Very often (80–99%) | In 2 conditions |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Very often (80–99%) | In 3 conditions |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Very often (80–99%) | In 1 condition |
| PDHA2pyruvate dehydrogenase E1 subunit alpha 2 | Very often (80–99%) | In 2 conditions |
| PNLDC1PARN like ribonuclease domain containing exonuclease 1 | Very often (80–99%) | In 1 condition |
| PROK2prokineticin 2 | Very often (80–99%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Very often (80–99%) | In 1 condition |
| RBBP7RB binding protein 7, chromatin remodeling factor | Very often (80–99%) | In 1 condition |
| RNF212ring finger protein 212 | Very often (80–99%) | In 1 condition |
| RPL10Lribosomal protein L10 like | Very often (80–99%) | In 1 condition |
| SHOC1shortage in chiasmata 1 | Very often (80–99%) | In 1 condition |
| SOHLH1spermatogenesis and oogenesis specific basic helix-loop-helix 1 | Very often (80–99%) | In 1 condition |
| SPAG17sperm associated antigen 17 | Very often (80–99%) | In 1 condition |
| SPINK2serine peptidase inhibitor Kazal type 2 | Very often (80–99%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Very often (80–99%) | In 1 condition |
| SRYsex determining region Y | Very often (80–99%) | In 3 conditions |
| STAG3STAG3 cohesin complex component | Very often (80–99%) | In 1 condition |
| STRCstereocilin | Very often (80–99%) | In 1 condition |
| SYCE1synaptonemal complex central element protein 1 | Very often (80–99%) | In 1 condition |
| TAC3tachykinin precursor 3 | Very often (80–99%) | In 1 condition |
| TACR3tachykinin receptor 3 | Very often (80–99%) | In 1 condition |
| TAF4BTATA-box binding protein associated factor 4b | Very often (80–99%) | In 2 conditions |
| TDRD9tudor domain containing 9 | Very often (80–99%) | In 2 conditions |
| TERB1telomere repeat binding bouquet formation protein 1 | Very often (80–99%) | In 1 condition |
| TERB2telomere repeat binding bouquet formation protein 2 | Very often (80–99%) | In 1 condition |
| TEX15testis expressed 15, meiosis and synapsis associated | Very often (80–99%) | In 1 condition |
| VAMP7vesicle associated membrane protein 7 | Very often (80–99%) | In 1 condition |
| WDR11WD repeat domain 11 | Very often (80–99%) | In 1 condition |
| WNT4Wnt family member 4 | Very often (80–99%) | In 1 condition |
| WT1WT1 transcription factor | Very often (80–99%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Very often (80–99%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Very often (80–99%) | In 1 condition |
| ZSWIM7zinc finger SWIM-type containing 7 | Very often (80–99%) | In 1 condition |
| ANK1ankyrin 1 | Often (30–79%) | In 1 condition |
| BRCC3BRCA1/BRCA2-containing complex subunit 3 | Often (30–79%) | In 1 condition |
| FSHBfollicle stimulating hormone subunit beta | Often (30–79%) | In 2 conditions |
| ARandrogen receptor | Sometimes (5–29%) | In 2 conditions |
| BLMBLM RecQ like helicase | Sometimes (5–29%) | In 2 conditions |
| BRCA1BRCA1 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Sometimes (5–29%) | In 1 condition |
| CFAP57cilia and flagella associated protein 57 | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| FAAP100FA core complex associated protein 100 | Sometimes (5–29%) | In 1 condition |
| FANCAFA complementation group A | Sometimes (5–29%) | In 1 condition |
| FANCBFA complementation group B | Sometimes (5–29%) | In 1 condition |
| FANCCFA complementation group C | Sometimes (5–29%) | In 1 condition |
| FANCD2FA complementation group D2 | Sometimes (5–29%) | In 1 condition |
| FANCEFA complementation group E | Sometimes (5–29%) | In 1 condition |
| FANCFFA complementation group F | Sometimes (5–29%) | In 1 condition |
| FANCGFA complementation group G | Sometimes (5–29%) | In 1 condition |
| FANCIFA complementation group I | Sometimes (5–29%) | In 1 condition |
| FANCLFA complementation group L | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Sometimes (5–29%) | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Sometimes (5–29%) | In 1 condition |
| RAD51RAD51 recombinase | Sometimes (5–29%) | In 1 condition |
| RAD51CRAD51 paralog C | Sometimes (5–29%) | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Sometimes (5–29%) | In 1 condition |
| SLX4SLX4 structure-specific endonuclease subunit | Sometimes (5–29%) | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Rarely (1–4%) | In 1 condition |
| MC2Rmelanocortin 2 receptor | Rarely (1–4%) | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Rarely (1–4%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Rarely (1–4%) | In 1 condition |
| STARsteroidogenic acute regulatory protein | Rarely (1–4%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Rarely (1–4%) | In 1 condition |
| ADGRG2adhesion G protein-coupled receptor G2 | Not recorded | In 1 condition |
| ANOS1anosmin 1 | Not recorded | In 1 condition |
| BCL10BCL10 immune signaling adaptor | Not recorded | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| BPY2basic charge Y-linked 2 | Not recorded | In 1 condition |
| CDY1chromodomain Y-linked 1 | Not recorded | In 1 condition |
| CDY2Achromodomain Y-linked 2A | Not recorded | In 1 condition |
| CEP19centrosomal protein 19 | Not recorded | In 1 condition |
| CFAP221cilia and flagella associated protein 221 | Not recorded | In 1 condition |
| DAZ1deleted in azoospermia 1 | Not recorded | In 1 condition |
| DAZ2deleted in azoospermia 2 | Not recorded | In 1 condition |
| DAZ3deleted in azoospermia 3 | Not recorded | In 1 condition |
| DDX3YDEAD-box helicase 3 Y-linked | Not recorded | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Not recorded | In 1 condition |
| HFEhomeostatic iron regulator | Not recorded | In 1 condition |
| HJVhemojuvelin BMP co-receptor | Not recorded | In 1 condition |
| HSFY1heat shock transcription factor Y-linked 1 | Not recorded | In 1 condition |
| KDM5Dlysine demethylase 5D | Not recorded | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Not recorded | In 1 condition |
| MCM8minichromosome maintenance 8 homologous recombination repair factor | Not recorded | In 1 condition |
| MSH4mutS homolog 4 | Not recorded | In 1 condition |
| PRYPTPN13 like Y-linked | Not recorded | In 1 condition |
| PRY2PTPN13 like Y-linked 2 | Not recorded | In 1 condition |
| RBMY1A1RNA binding motif protein Y-linked family 1 member A1 | Not recorded | In 1 condition |
| RPS4Y2ribosomal protein S4 Y-linked 2 | Not recorded | In 1 condition |
| SEMA3Asemaphorin 3A | Not recorded | In 1 condition |
| STK11serine/threonine kinase 11 | Not recorded | In 1 condition |
| USP9Yubiquitin specific peptidase 9 Y-linked | Not recorded | In 1 condition |
| VCYvariable charge Y-linked | Not recorded | In 1 condition |
| XKRYXK related, Y-linked (pseudogene) | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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