Trait
Minimal change glomerulonephritis
The presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria.
Summary
- Also called
- Minimal change disease, Minimal change nephropathy
Reference genomeGRCh38hg38
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Changes in these genes cause rare conditions in which Minimal change glomerulonephritis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EMP2epithelial membrane protein 2 | Always | In 2 conditions |
| KANK2KN motif and ankyrin repeat domains 2 | Always | In 2 conditions |
| ARPC5actin related protein 2/3 complex subunit 5 | Often (30–79%) | In 1 condition |
| KIRREL1kirre like nephrin family adhesion molecule 1 | Often (30–79%) | In 1 condition |
| LAGE3L antigen family member 3 | Often (30–79%) | In 1 condition |
| MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 | Often (30–79%) | In 2 conditions |
| PTPROprotein tyrosine phosphatase receptor type O | Often (30–79%) | In 2 conditions |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Often (30–79%) | In 1 condition |
| ACTN4actinin alpha 4 | Sometimes (5–29%) | In 1 condition |
| ANKFY1ankyrin repeat and FYVE domain containing 1 | Sometimes (5–29%) | In 1 condition |
| ANLNanillin, actin binding protein | Sometimes (5–29%) | In 1 condition |
| APOL1apolipoprotein L1 | Sometimes (5–29%) | In 1 condition |
| ARHGAP24Rho GTPase activating protein 24 | Sometimes (5–29%) | In 1 condition |
| ARHGDIARho GDP dissociation inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| AVILadvillin | Sometimes (5–29%) | In 1 condition |
| CD2APCD2 associated protein | Sometimes (5–29%) | In 1 condition |
| COL4A3collagen type IV alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| COQ8Bcoenzyme Q8B | Sometimes (5–29%) | In 1 condition |
| CRB2crumbs cell polarity complex component 2 | Sometimes (5–29%) | In 1 condition |
| DAAM2dishevelled associated activator of morphogenesis 2 | Sometimes (5–29%) | In 1 condition |
| GAPVD1GTPase activating protein and VPS9 domains 1 | Sometimes (5–29%) | In 1 condition |
| INF2inverted formin 2 | Sometimes (5–29%) | In 1 condition |
| LAMA5laminin subunit alpha 5 | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| MYO1Emyosin IE | Sometimes (5–29%) | In 1 condition |
| NPHS1NPHS1 adhesion molecule, nephrin | Sometimes (5–29%) | In 1 condition |
| NPHS2NPHS2 stomatin family member, podocin | Sometimes (5–29%) | In 1 condition |
| NUP107nucleoporin 107 | Sometimes (5–29%) | In 3 conditions |
| NUP133nucleoporin 133 | Sometimes (5–29%) | In 1 condition |
| NUP160nucleoporin 160 | Sometimes (5–29%) | In 1 condition |
| NUP205nucleoporin 205 | Sometimes (5–29%) | In 1 condition |
| NUP37nucleoporin 37 | Sometimes (5–29%) | In 1 condition |
| NUP85nucleoporin 85 | Sometimes (5–29%) | In 1 condition |
| NUP93nucleoporin 93 | Sometimes (5–29%) | In 1 condition |
| PAX2paired box 2 | Sometimes (5–29%) | In 1 condition |
| PLCE1phospholipase C epsilon 1 | Sometimes (5–29%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Sometimes (5–29%) | In 1 condition |
| TBC1D8BTBC1 domain family member 8B | Sometimes (5–29%) | In 1 condition |
| TRPC6transient receptor potential cation channel subfamily C member 6 | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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