Trait
Heart tip and four chambers point towards right side of body
Clinical name: Dextrocardia
The heart is located in the right hand sided hemithorax. That is, there is a left-right reversal (or "mirror reflection") of the anatomical location of the heart in which the heart is locate on the right side instead of the left.
Summary
- Also called
- Thoracic situs inversus
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Read the genes linked to Heart tip and four chambers point towards right side of body, and the rest of your genome, with one test.
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Get my Genome Test58 genes linked to Heart tip and four chambers point towards right side of body
Changes in these genes cause rare conditions in which Heart tip and four chambers point towards right side of body is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DAND5DAN domain BMP antagonist family member 5 | Always | In 1 condition |
| DNAH1dynein axonemal heavy chain 1 | Always | In 1 condition |
| DNAH11dynein axonemal heavy chain 11 | Always | In 1 condition |
| LZTFL1leucine zipper transcription factor like 1 | Always | In 1 condition |
| ZIC3Zic family zinc finger 3 | Always | In 2 conditions |
| ACVR2Bactivin A receptor type 2B | Often (30–79%) | In 1 condition |
| CFAP300cilia and flagella associated protein 300 | Often (30–79%) | In 1 condition |
| CFAP52cilia and flagella associated protein 52 | Often (30–79%) | In 1 condition |
| CFAP53cilia and flagella associated protein 53 | Often (30–79%) | In 1 condition |
| CFC1cryptic, EGF-CFC family member 1 | Often (30–79%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Often (30–79%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Often (30–79%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Often (30–79%) | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Often (30–79%) | In 1 condition |
| GDF1growth differentiation factor 1 | Often (30–79%) | In 1 condition |
| GLI1GLI family zinc finger 1 | Often (30–79%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 1 condition |
| MNS1meiosis specific nuclear structural 1 | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 1 condition |
| ODAD3outer dynein arm docking complex subunit 3 | Often (30–79%) | In 1 condition |
| PKD1L1polycystin 1 like 1, transient receptor potential channel interacting | Often (30–79%) | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Often (30–79%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| AHI1Abelson helper integration site 1 | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| CDH2cadherin 2 | Sometimes (5–29%) | In 1 condition |
| CEP120centrosomal protein 120 | Sometimes (5–29%) | In 1 condition |
| CEP41centrosomal protein 41 | Sometimes (5–29%) | In 1 condition |
| CIROPciliated left-right organizer metallopeptidase | Sometimes (5–29%) | In 1 condition |
| COL18A1collagen type XVIII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| DNAAF19dynein axonemal assembly factor 19 | Sometimes (5–29%) | In 1 condition |
| DNAAF4dynein axonemal assembly factor 4 | Sometimes (5–29%) | In 1 condition |
| FAAP100FA core complex associated protein 100 | Sometimes (5–29%) | In 1 condition |
| FRYLFRY like transcription coactivator | Sometimes (5–29%) | In 1 condition |
| IFT56intraflagellar transport 56 | Sometimes (5–29%) | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Sometimes (5–29%) | In 1 condition |
| LMBRD1LMBR1 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| LRRC56leucine rich repeat containing 56 | Sometimes (5–29%) | In 1 condition |
Show 18 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MKS1MKS transition zone complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| MMP21matrix metallopeptidase 21 | Sometimes (5–29%) | In 1 condition |
| ODAD1outer dynein arm docking complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| PACS2phosphofurin acidic cluster sorting protein 2 | Sometimes (5–29%) | In 1 condition |
| PAK2p21 (RAC1) activated kinase 2 | Sometimes (5–29%) | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Sometimes (5–29%) | In 2 conditions |
| PKD2polycystin 2, transient receptor potential cation channel | Sometimes (5–29%) | In 1 condition |
| ROBO1roundabout guidance receptor 1 | Sometimes (5–29%) | In 1 condition |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Sometimes (5–29%) | In 1 condition |
| ZMYND10zinc finger MYND-type containing 10 | Sometimes (5–29%) | In 1 condition |
| GATA4GATA binding protein 4 | Rarely (1–4%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Rarely (1–4%) | In 1 condition |
| DNAAF3dynein axonemal assembly factor 3 | Not recorded | In 1 condition |
| HES7hes family bHLH transcription factor 7 | Not recorded | In 1 condition |
| MYRFmyelin regulatory factor | Not recorded | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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