Variant
WT1 H450Y
NM_024426.6(WT1):c.1348C>T (p.His450Tyr)
- H377Y
- p.His450Tyr
- p.H450Y
- rs28942089
- ClinVar classification
- Pathogenic/likely pathogenic
- Review status
- 2 stars out of 4criteria provided, multiple submitters, no conflicts
- Last evaluated
- 9 October 2022
Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.16-c6eea6bfFacts last changed 16 October 2026
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Summary
H450Y is a missense variant in WT1: it changes a single amino acid in the protein the gene encodes. ClinVar classifies it as pathogenic or likely pathogenic for Denys-Drash syndrome (criteria provided, multiple submitters, no conflicts).
ClinVar classifications
| Condition | Classification | Review status | Submissions | Last evaluated |
|---|---|---|---|---|
| Denys-Drash syndromeClinVar VCV000003495 (opens in a new tab) | Pathogenic/likely pathogenic | 2 stars out of 4criteria provided, multiple submitters, no conflicts | 2 submissions | 9 October 2022 |
Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed.
Where it lies in WT1
H450Y lies in exon 8 of the 10 in WT1's MANE Select transcript, NM_024426.6.
Molecular details
| Gene | WT1 |
|---|---|
| Transcript | NM_024426.6MANE Select |
| Coding DNA change (HGVS c.) | c.1348C>T |
| Protein change (HGVS p.) | p.His450Tyrp.H450Y |
| Predicted consequence | Missensemissense_variant (opens in a new tab) |
| Predicted impact | Moderate |
| Position (GRCh38) | chr11:32392672 G>A |
| Position (GRCh37) | chr11:32414218 G>A |
| dbSNP ID | rs28942089 (opens in a new tab) |
| ClinVar Variation ID | VCV000003495 (opens in a new tab) |
| ClinVar Allele ID | 18534 |
| ClinGen Allele Registry ID | CA016298 (opens in a new tab) |
| ClinVar name | NM_024426.6(WT1):c.1348C>T (p.His450Tyr) |
| Other names | H377Y |
WT1 H450Y in other databases
Reports that look at this variant (1)
These Genome Test condition reports include H450Y among the variants they look at.
| Report | Conditions | Inheritance |
|---|---|---|
| 46,XY Differences of Sex Development and Gonadal Dysgenesis | 46,XY differences of sex development |
Other variants in WT1
- c.965+1G>ALikely pathogenic2 stars out of 4
- c.1447+4C>T1432+4C>TPathogenic2 stars out of 4
- c.1447+5G>A1432+5G>APathogenic2 stars out of 4
- c.1448-1G>ALikely pathogenic2 stars out of 4
- G152Afs*11Pathogenic/likely pathogenic2 stars out of 4
- H446QPathogenic2 stars out of 4
- P137Rfs*26Pathogenic/likely pathogenic2 stars out of 4
- Q462XLikely pathogenic2 stars out of 4
- R374XPathogenic2 stars out of 4
- R385Gfs*5Pathogenic/likely pathogenic2 stars out of 4
Limitations
This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant.
Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports.
Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements.
If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor.
Sources & credits
- Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information.
- Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0.
- Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16).
- Allele identifiers from the ClinGen Allele Registry (release 2026-10-16-c4908f54).
- Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information.
- Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-16).
- Difficult regions from the Genome in a Bottle Consortium (release v3.6).
- Transcripts from MANE (release v1.5), NCBI and EMBL-EBI.
- Predicted consequences from mehari (release 0.11.0), with transcript models from cdot.
- Built from Dante Labs data release 2026.10.16-c6eea6bf of 16 October 2026.
Cite this page
Dante Labs. (16 October 2026). WT1 H450Y (c.1348C>T, rs28942089) (Version 2026.10.16-c6eea6bf). Retrieved 17 October 2026, from https://dantelabs.com/genes/wt1/variants/h450y
Dante Labs. WT1 H450Y (c.1348C>T, rs28942089) [Internet]. Version 2026.10.16-c6eea6bf. 16 October 2026 [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wt1/variants/h450y
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