Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Primary gonadal insufficiency, and the rest of your genome, with one test.
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Get my Genome Test17 genes linked to Primary gonadal insufficiency
Changes in these genes cause rare conditions in which Primary gonadal insufficiency is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CYB5Acytochrome b5 type A | Very often (80–99%) | In 1 condition |
| CYP17A1cytochrome P450 family 17 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Very often (80–99%) | In 1 condition |
| XRCC4X-ray repair cross complementing 4 | Very often (80–99%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Often (30–79%) | In 1 condition |
| DHX37DEAH-box helicase 37 | Sometimes (5–29%) | In 1 condition |
| GATA4GATA binding protein 4 | Sometimes (5–29%) | In 1 condition |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Sometimes (5–29%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Sometimes (5–29%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Sometimes (5–29%) | In 1 condition |
| SRYsex determining region Y | Sometimes (5–29%) | In 1 condition |
| VAMP7vesicle associated membrane protein 7 | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Sometimes (5–29%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Sometimes (5–29%) | In 1 condition |
| EIF2B1eukaryotic translation initiation factor 2B subunit alpha | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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