AtlasGen
RNU4-2
RNA, U4 small nuclear 2
- HGNC 10193↗(åbnes i en ny fane)
- Ensembl-gen ENSG00000202538↗(åbnes i en ny fane)
- NCBI Gene 26834↗(åbnes i en ny fane)
Oversigt
- Cytogenetisk placering
- 12q24.31
- Koordinater
- Kromosom 12: 120.291.759–120.291.903 (GRCh38)
- Exoner
- 1 exon fordelt over 0,1 kb
- Også kendt som
- U4c, U4b, U4A
- Tidligere symboler
- RNU4C, RNU4-1B, RNU4B1
- MANE Select-transkript
- ENST00000365668.2NR_003137.3
- Lokustype
- Small nuclear RNA (snRNA)
AtlasDenne side som data
Tilføj .json til sidens adresse, eller bed om application/json, for at læse den som JSON.
library(jsonlite)
url <- "https://dantelabs.com/genes/rnu4-2.json"
page <- fromJSON(url)
page$gene$nameLæs RNU4-2 og resten af dit genom med én test.
Fra 449 $Gratis forsendelse · Resultater på 6–8 uger
Bestil min Genome TestKurerede rapporter relevant for dette gen
Ingen Genome Test-rapport læser RNU4-2 endnu. Testen sekventerer hele dit genom, så dine data omfatter det alligevel.
Sådan er RNU4-2 opbygget
- Utranslateret region
- Intron
- Transkriptionsretning
- Kendte sygdomsfremkaldende steder
Eksoner i genets MANE Select-transkript (udgave v1.5), fra NCBI og EMBL-EBI, på referencegenomet GRCh38.
Kromosombånd fra UCSC's GRCh38-ideogram (2022-10-29).
Gener i nærheden fra Ensembl-udgivelse 116, på GRCh38.
Eksoner udgør 0,1 kb af genets 0,1 kb.
Sekventering af RNU4-2
22
positioner i RNU4-2, hvor ClinVar klassificerer en ændring som patogen eller sandsynligvis patogen
Ingen af dem ligger i en region, som korte læsninger har svært ved at dække.
En helgenomsanalyse dækker alle 0,1 kb af RNU4-2, inklusive introner, og ikke kun de 0,1 kb eksoner.
Træk knyttet til RNU4-2
Human Phenotype Ontology angiver disse som kendetegn ved de sjældne tilstande, RNU4-2 kan forårsage. Hvert træks side viser de andre gener, der er knyttet til det.
Abnormality of head or neck
- Abnormally small head
- Progressively abnormally small cranium
- Decreased facial muscle tone
- Eye folds
- Full lips
- High palate
- Narrow palate
- Open mouth
Vis 60 træk mere
- Small head present at birth
- Tented mouth
- Tented philtrum
- Abnormally large tongue
- Almond shaped eyes
- Broad nasal tip
- Cleft nasal tip
- Depressed nasal bridge
- Development of small head that was not present at birth
- Drooling
- Enlarged cisterna magna
- Full cheeks
- High forehead
- Horizontal eyebrow
- Little lower jaw
- Long eyelashes
- Long face
- Low hanging columella
- Lower eyelid folded out
- Narrow forehead
- Narrow opening between the eyelids
- Nasal tip, upturned
- Protruding tongue
- Receding chin
- Short philtrum
- Thickened skin folds of neck
- Triangular face
- Abnormal dental position
- Bifid uvula
- Broad head shape
- Bulbous nose
- Carp-like mouth
- Corners of eye widely separated
- Deep philtrum
- Downturned corners of mouth
- Downward slanting of the opening between the eyelids
- Eversion of lateral third of lower eyelids
- Facial asymmetry
- Flat back of skull
- Flat face
- Full lower lip
- Long neck
- Narrow eyelid opening
- Narrow mouth
- Narrow nose
- Opacified paranasal sinuses
- Prominent metopic ridge
- Prominent nasal bridge
- Scaphocephaly
- Short chin
- Short neck
- Short nose
- Sloping forehead
- Smooth philtrum
- Thin red part of the upper lip
- Triangular-shaped open mouth
- Underdeveloped tissue around nostril
- Upward slanting of the opening between the eyelids
- Wide mouth
- Wide nasal bridge
Abnormality of the nervous system
- Abnormal cerebral white matter morphology
- Abnormal gait
- Anxiety
- Brain degeneration
- Degeneration of cerebrum
- Delayed speech and language development
- Gliosis
- Global developmental delay
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- Gray matter heterotopia
- Intellectual disability
- Motor delay
- Restricted or repetitive behaviors or interests
- Self-injurious behavior
- Sensory seeking
- Thin corpus callosum
- Absent speech development
- Delayed ability to walk
- Intellectual disability, severe
- Short attention span
- Absent/small cerebral white matter
- Autism spectrum disorder
- Epilepsy
- Periventricular heterotopia
- Repetitive movements
- Severe global developmental delay
- Aggressive behavior
- Arachnoid granulation
- Cerebral palsy
- Clonus
- Colpocephaly
- Delayed CNS myelination
- Difficulty sleeping
- Hippocampal atrophy
- Inability to walk
- IQ between 34 and 49
- Irritability
- Moderate global developmental delay
- Motor axonal neuropathy
- Reduced cerebral white matter volume
- Self-biting
- Underdevelopment of part of brain called corpus callosum
- Unsteady walk
- Ventriculomegaly
- Ataxia
- Bipolar disorder
- Cavum septum pellucidum
- Chiari malformation
- Choreoathetosis
- Communicating hydrocephalus
- Dystonia
- Eye poking
- Fewer or absent grooves in brain
- Fluid-filled sac located in membrane surrounding brain or spinal cord
- Generalized brain degeneration
- Hyperintensity of cerebral white matter on MRI
- Obsessive compulsive behavior
- Periventricular leukomalacia
- Periventricular nodular heterotopia
- Pica
- Social anxiety
- Wide based walk
Abnormality of the eye
- Abnormal electroretinogram
- Abnormal retinal pigmentation
- Blindness
- Extreme sensitivity of the eyes to light
- Involuntary, rapid, rhythmic eye movements
- Optic atrophy
- Progressive night blindness
- Retina degeneration
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- Spicular pigmentation of the retina
- Visual impairment
- Abnormal central response of multifocal electroretinogram
- Abnormal full-field electroretinogram
- Astigmatism
- Bulging cornea
- Cross-eyed
- Cystoid macular edema
- Difficulties with night vision
- Eye muscle paralysis
- Glaucoma
- Loss of peripheral vision
- Optic disc drusen
- Optic disc pallor
- Photoreceptor outer segment loss on macular OCT
- Posterior subcapsular cataract
- Retinal atrophy
- Abnormal color vision
- Abnormally close eyes
- Blue outer white part of eyeball
- Close sighted
- Decreased clarity of vision
- Farsightedness
- Increased size of eyes
- Optic nerve hypoplasia
- Photopsia
- Deeply set eye
- Wide-set eyes
Eksterne links
Genposter
Transkript
Hvor oplysningerne kommer fra
- HGNC: genets symbol, navn, andre symboler og placering.
- MANE Select v1.5, fra NCBI og EMBL-EBI: transkriptet, dets exoner og kodende sekvens.
- ClinVar og GIAB-stratifikationerne: kendte sygdomsfremkaldende positioner og de regioner, som korte læsninger har svært ved at aflæse.
- Human Phenotype Ontology, version 2026-09-01: de træk, der er knyttet til genet. Læs mere på hpo.jax.org.
- Dataudgivelse 2026.10.16-c6eea6bf.
Citér denne side
Dante Labs. (u.d.). RNU4-2-genet: RNA, U4 small nuclear 2. Hentet 17. oktober 2026, fra https://dantelabs.com/da/genes/rnu4-2
Dante Labs. RNU4-2-genet: RNA, U4 small nuclear 2 [Internet]. [citeret 17. oktober 2026]. Tilgængelig fra: https://dantelabs.com/da/genes/rnu4-2
AtlasÉn test. Svar for hele livet.
Fra 449 $Gratis forsendelse · Resultater på 6–8 uger