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Gene

DSTYK

dual serine/threonine and tyrosine protein kinase

Summary

Cytogenetic location
1q32.1
Coordinates
Chromosome 1: 205,142,505–205,211,702 (GRCh38)
Exons
13 exons across 69.2 kb
Protein
929 amino acids
Also known as
KIAA0472, DustyPK, RIP5
Previous symbols
RIPK5, SPG23
MANE Select transcript
ENST00000367162.8NM_015375.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Anomalies of the Kidney and Urinary Tract

    • Congenital Anomaly of Kidney and Urinary Tract

      A broad group of developmental kidney and urinary tract malformations; genetic causes include variants in PAX2, HNF1B, GREB1L and other genes, often with variable penetrance.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing can prompt kidney imaging and function checks in the person and relatives.

Broader groupings

  • Hereditary Spastic Paraplegia

    • Hereditary Spastic Paraplegia (All Types)

      One of 66 genes linked to it

      Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

How DSTYK is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where DSTYK sits. DSTYK and 14 genes near it on chromosome 1, from 204,677,104 to 205,677,103.Chromosome 11q32.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44204.8 Mb205 Mb205.2 Mb205.4 Mb205.6 MbLRRN2: 204,617,170–204,685,745, reverse strandLRRN2NFASC: 204,828,651–205,022,822, forward strandNFASCCNTN2: 205,042,937–205,078,289, forward strandCNTN2TMEM81: 205,083,129–205,084,460, reverse strandTMEM81RBBP5: 205,085,685–205,122,263, reverse strandRBBP5DSTYK: 205,142,505–205,211,702, reverse strandDSTYKTMCC2: 205,227,912–205,285,632, forward strandTMCC2NUAK2: 205,302,059–205,321,781, reverse strandNUAK2KLHDC8A: 205,333,749–205,357,324, reverse strandKLHDC8ALEMD1: 205,381,376–205,456,415, reverse strandLEMD1BLACAT1: 205,434,852–205,457,390, reverse strandBLACAT1CDK18: 205,504,551–205,532,976, forward strandCDK18SLC60A1: 205,568,833–205,602,918, forward strandSLC60A1ELK4: 205,597,374–205,634,520, reverse strandELK4SLC45A3: 205,657,851–205,680,990, reverse strandSLC45A3Diagram of DSTYK: 13 exons on the reverse strand of chromosome 1Exon 4: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 13: 205,142,505–205,147,745, 5,241 basesExon 12: 205,148,205–205,148,339, 135 basesExon 11: 205,150,680–205,150,794, 115 basesExon 10: 205,157,273–205,157,386, 114 basesExon 9: 205,159,547–205,159,679, 133 basesExon 8: 205,160,114–205,160,270, 157 basesExon 7: 205,161,258–205,161,387, 130 basesExon 6: 205,162,036–205,162,212, 177 basesExon 5: 205,162,923–205,163,006, 84 basesExon 4: 205,163,723–205,163,955, 233 basesExon 3: 205,169,163–205,169,832, 670 basesExon 2: 205,187,418–205,187,806, 389 basesExon 1: 205,211,271–205,211,702, 432 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 69.2 kb; 2,790 of those bases code for the protein.

How a genome test reads DSTYK

5

positions in DSTYK where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 69.2 kb of DSTYK, introns included, not only the 8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DSTYK gene: dual serine/threonine and tyrosine protein kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/dstyk

Vancouver

Dante Labs. DSTYK gene: dual serine/threonine and tyrosine protein kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dstyk

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