Gene
TRIM63
tripartite motif containing 63
- HGNC 16007(opens in a new tab)
- Ensembl gene ENSG00000158022(opens in a new tab)
- NCBI Gene 84676(opens in a new tab)
Summary
- Cytogenetic location
- 1p36.11
- Coordinates
- Chromosome 1: 26,051,301–26,067,630 (GRCh38)
- Exons
- 9 exons across 16.3 kb
- Protein
- 353 amino acids
- Inheritance
- Autosomal dominant
- Also known as
- MURF-1, IRF, SMRZ
- Previous symbols
- RNF28
- MANE Select transcript
- ENST00000374272.4NM_032588.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Hypertrophic Cardiomyopathy
- Autosomal dominant
One of 62 genes linked to it
A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.
- ClinGen rates the link moderate
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How TRIM63 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.8 kb of the gene's 16.3 kb; 1,062 of those bases code for the protein.
How a genome test reads TRIM63
4
positions in TRIM63 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 16.3 kb of TRIM63, introns included, not only the 1.8 kb of exons.
Traits linked to TRIM63
The Human Phenotype Ontology lists these as features of the rare conditions TRIM63 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the musculoskeletal system
- Centrally nucleated skeletal muscle fibers
- Difficulty walking up stairs
- EMG: myopathic abnormalities
- Fatty replacement of skeletal muscle
- Increased endomysial connective tissue
- Increased variability in muscle fiber diameter
- Muscle tissue disease
- Proximal neurogenic muscle weakness
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TRIM63 gene: tripartite motif containing 63. Retrieved 17 October 2026, from https://dantelabs.com/genes/trim63
Dante Labs. TRIM63 gene: tripartite motif containing 63 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trim63
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