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Gene

DPM3

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

Summary

Cytogenetic location
1q22
Coordinates
Chromosome 1: 155,139,891–155,140,531 (GRCh38)
Exons
2 exons across 0.6 kb
Protein
92 amino acids
Also known as
MGC34275, MGC125904, MGC125905
MANE Select transcript
ENST00000368400.5NM_153741.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Muscular Dystrophies

    • Congenital muscular dystrophy

      A group of muscular dystrophies with onset at birth or in infancy, including dystroglycanopathies (such as FKRP, FKTN and POMT1/2-related forms).

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong

How DPM3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 1, with a bracket where DPM3 sits. DPM3 and 34 genes near it on chromosome 1, from 154,640,211 to 155,640,210.Chromosome 11q22p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44154.8 Mb155 Mb155.2 Mb155.4 Mb155.6 MbKCNN3: 154,697,455–154,870,340, reverse strandKCNN3PMVK: 154,924,732–154,937,008, reverse strandPMVKPBXIP1: 154,944,059–154,956,451, reverse strandPYGO2: 154,957,025–154,963,853, reverse strandSHC1: 154,962,284–154,974,452, reverse strandSHC1CKS1B: 154,974,641–154,979,256, forward strandCKS1BFLAD1: 154,983,311–154,993,111, forward strandFLAD1LENEP: 154,993,586–154,994,315, forward strandLENEPZBTB7B: 155,002,543–155,018,525, forward strandDCST2: 155,018,520–155,033,781, reverse strandDCST1: 155,033,824–155,050,930, forward strandADAM15: 155,050,566–155,062,780, forward strandADAM15EFNA4: 155,063,718–155,069,553, forward strandEFNA4EFNA4-EFNA3: 155,063,748–155,086,807, forward strandEFNA4-EFNA3EFNA3: 155,078,823–155,087,538, forward strandEFNA3EFNA1: 155,127,452–155,134,899, forward strandEFNA1SLC50A1: 155,135,344–155,138,857, forward strandSLC50A1DPM3: 155,139,891–155,140,531, reverse strandDPM3KRTCAP2: 155,169,182–155,173,475, reverse strandKRTCAP2: 155,169,409–155,187,272, reverse strandTRIM46: 155,173,787–155,184,971, forward strandMUC1: 155,185,824–155,192,916, reverse strandMUC1THBS3: 155,195,584–155,209,203, reverse strandMTX1: 155,208,695–155,213,824, forward strandGBA1: 155,231,270–155,245,178, reverse strandGBA1ENTREP3: 155,247,205–155,255,824, reverse strandENTREP3SCAMP3: 155,255,979–155,262,433, reverse strandSCAMP3CLK2: 155,262,747–155,278,491, reverse strandCLK2HCN3: 155,277,328–155,289,848, forward strandHCN3PKLR: 155,289,265–155,301,443, reverse strandFDPS: 155,304,786–155,320,666, forward strandFDPSRUSC1: 155,320,739–155,331,422, forward strandRUSC1ASH1L: 155,335,268–155,563,162, reverse strandASH1LMSTO1: 155,563,235–155,616,644, forward strandMSTO1: 155,626,755–155,648,640, reverse strandDiagram of DPM3: 2 exons on the reverse strand of chromosome 1Exon 2: 11 known disease-causing sitesExon 2: 155,139,891–155,140,245, 355 basesExon 1: 155,140,491–155,140,531, 41 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.4 kb of the gene's 0.6 kb; 279 of those bases code for the protein.

How a genome test reads DPM3

11

positions in DPM3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 0.6 kb of DPM3, introns included, not only the 0.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DPM3 gene: dolichyl-phosphate mannosyltransferase subunit 3, regulatory. Retrieved 16 October 2026, from https://dantelabs.com/genes/dpm3

Vancouver

Dante Labs. DPM3 gene: dolichyl-phosphate mannosyltransferase subunit 3, regulatory [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dpm3

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