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Trait

Migraine with aura

A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.

HPO HP:0002077

Summary

Body system
Abnormality of the nervous system

12 genes linked to Migraine with aura

Changes in these genes cause rare conditions in which Migraine with aura is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
SCN1Asodium voltage-gated channel alpha subunit 1AlwaysIn 2 conditions
ATP1A2ATPase Na+/K+ transporting subunit alpha 2Very often (80–99%)In 2 conditions
CACNA1Acalcium voltage-gated channel subunit alpha1 AVery often (80–99%)In 2 conditions
PRRT2proline rich transmembrane protein 2Very often (80–99%)In 1 condition
COL4A1collagen type IV alpha 1 chainOften (30–79%)In 1 condition
NOTCH3notch receptor 3Often (30–79%)In 1 condition
TREX1three prime repair exonuclease 1Sometimes (5–29%)In 1 condition
CSNK1Dcasein kinase 1 deltaNot recordedIn 1 condition
EDNRAendothelin receptor type ANot recordedIn 1 condition
ESR1estrogen receptor 1Not recordedIn 1 condition
KCNK18potassium two pore domain channel subfamily K member 18Not recordedIn 1 condition
TNFtumor necrosis factorNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Migraine

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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