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Trait

Migraine without aura

Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.

HPO HP:0002083

Summary

Body system
Abnormality of the nervous system

8 genes linked to Migraine without aura

Changes in these genes cause rare conditions in which Migraine without aura is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
LAMB1laminin subunit beta 1AlwaysIn 1 condition
CACNA1Acalcium voltage-gated channel subunit alpha1 AOften (30–79%)In 1 condition
TREX1three prime repair exonuclease 1Sometimes (5–29%)In 1 condition
CSNK1Dcasein kinase 1 deltaNot recordedIn 1 condition
EDNRAendothelin receptor type ANot recordedIn 1 condition
ESR1estrogen receptor 1Not recordedIn 1 condition
KCNK18potassium two pore domain channel subfamily K member 18Not recordedIn 1 condition
TNFtumor necrosis factorNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Migraine

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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