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Gene

ALPK1

alpha kinase 1

Summary

Cytogenetic location
4q25
Coordinates
Chromosome 4: 112,297,369–112,442,621 (GRCh38)
Exons
16 exons across 145.3 kb
Protein
1,244 amino acids
Also known as
Lak, FLJ22670, KIAA1527
MANE Select transcript
ENST00000650871.1NM_025144.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads ALPK1 yet. The test sequences your whole genome, so your data includes it all the same.

How ALPK1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where ALPK1 sits. ALPK1 and 7 genes near it on chromosome 4, from 111,869,995 to 112,869,994.Chromosome 44q25p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2112 Mb112.2 Mb112.4 Mb112.6 Mb112.8 MbFAM241A: 112,145,408–112,195,256, forward strandFAM241AAP1AR: 112,231,363–112,273,110, forward strandAP1ARTIFA: 112,272,966–112,302,436, reverse strandTIFAALPK1: 112,297,369–112,442,621, forward strandALPK1NEUROG2: 112,513,516–112,516,180, reverse strandNEUROG2ZGRF1: 112,534,428–112,637,402, reverse strandZGRF1LARP7: 112,636,990–112,657,861, forward strandLARP7ANK2: 112,818,032–113,384,237, forward strandANK2Diagram of ALPK1: 16 exons on the forward strand of chromosome 4Exon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 1: 112,297,369–112,297,469, 101 basesExon 2: 112,315,801–112,315,852, 52 basesExon 3: 112,377,678–112,377,898, 221 basesExon 4: 112,382,398–112,382,552, 155 basesExon 5: 112,411,827–112,412,025, 199 basesExon 6: 112,423,944–112,424,003, 60 basesExon 7: 112,425,665–112,425,751, 87 basesExon 8: 112,426,467–112,426,543, 77 basesExon 9: 112,427,570–112,427,665, 96 basesExon 10: 112,429,149–112,429,253, 105 basesExon 11: 112,430,448–112,432,581, 2,134 basesExon 12: 112,435,148–112,435,301, 154 basesExon 13: 112,438,484–112,438,646, 163 basesExon 14: 112,439,686–112,439,872, 187 basesExon 15: 112,440,917–112,441,105, 189 basesExon 16: 112,441,203–112,442,621, 1,419 bases110165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 145.3 kb; 3,735 of those bases code for the protein.

Sequencing ALPK1

2

positions in ALPK1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 145.3 kb of ALPK1, introns included, not only the 5.4 kb of exons.

Traits linked to ALPK1

The Human Phenotype Ontology lists these as features of the rare conditions ALPK1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). ALPK1 gene: alpha kinase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/alpk1

Vancouver

Dante Labs. ALPK1 gene: alpha kinase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alpk1

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