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Gene

ITCH

itchy E3 ubiquitin protein ligase

Summary

Cytogenetic location
20q11.22
Coordinates
Chromosome 20: 34,363,273–34,511,773 (GRCh38)
Exons
25 exons across 148.5 kb
Protein
862 amino acids
Also known as
AIP4
MANE Select transcript
ENST00000374864.10NM_031483.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ITCH yet. The test sequences your whole genome, so your data includes it all the same.

How ITCH is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where ITCH sits. ITCH and 13 genes near it on chromosome 20, from 33,937,523 to 34,937,522.Chromosome 2020q11.22p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3334 Mb34.2 Mb34.4 Mb34.6 Mb34.8 MbRALY: 33,993,632–34,108,308, forward strandRALYEIF2S2: 34,088,309–34,112,284, reverse strandEIF2S2ASIP: 34,194,569–34,269,346, forward strandASIPAHCY: 34,280,263–34,311,802, reverse strandAHCY: 34,363,271–34,540,923, forward strandITCH: 34,363,273–34,511,773, forward strandITCHDYNLRB1: 34,515,600–34,540,958, forward strandDYNLRB1MAP1LC3A: 34,546,838–34,560,357, forward strandMAP1LC3APIGU: 34,560,542–34,698,790, reverse strandPIGUNCOA6: 34,689,097–34,825,739, reverse strandNCOA6TP53INP2: 34,701,662–34,713,442, forward strandTP53INP2GGT7: 34,844,714–34,872,888, reverse strandGGT7ACSS2: 34,872,146–34,927,962, forward strandACSS2GSS: 34,928,432–34,956,027, reverse strandGSSDiagram of ITCH: 25 exons on the forward strand of chromosome 20Exon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 11: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 18: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 1: 34,363,273–34,363,349, 77 basesExon 2: 34,369,394–34,369,470, 77 basesExon 3: 34,393,791–34,393,881, 91 basesExon 4: 34,408,651–34,408,792, 142 basesExon 5: 34,412,515–34,412,639, 125 basesExon 6: 34,413,742–34,413,879, 138 basesExon 7: 34,424,480–34,424,525, 46 basesExon 8: 34,438,474–34,438,631, 158 basesExon 9: 34,440,155–34,440,344, 190 basesExon 10: 34,442,208–34,442,303, 96 basesExon 11: 34,445,287–34,445,461, 175 basesExon 12: 34,449,411–34,449,480, 70 basesExon 13: 34,457,390–34,457,474, 85 basesExon 14: 34,462,093–34,462,221, 129 basesExon 15: 34,470,048–34,470,120, 73 basesExon 16: 34,471,444–34,471,515, 72 basesExon 17: 34,477,772–34,477,860, 89 basesExon 18: 34,479,630–34,479,789, 160 basesExon 19: 34,480,599–34,480,732, 134 basesExon 20: 34,481,066–34,481,206, 141 basesExon 21: 34,489,266–34,489,386, 121 basesExon 22: 34,489,822–34,489,926, 105 basesExon 23: 34,492,501–34,492,597, 97 basesExon 24: 34,504,331–34,504,403, 73 basesExon 25: 34,507,695–34,511,773, 4,079 bases15101520255′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.7 kb of the gene's 148.5 kb; 2,589 of those bases code for the protein.

How a genome test reads ITCH

16

positions in ITCH where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 148.5 kb of ITCH, introns included, not only the 6.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITCH gene: itchy E3 ubiquitin protein ligase. Retrieved 16 October 2026, from https://dantelabs.com/genes/itch

Vancouver

Dante Labs. ITCH gene: itchy E3 ubiquitin protein ligase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/itch

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