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Gene

LIPE

lipase E, hormone sensitive type

Summary

Cytogenetic location
19q13.2
Coordinates
Chromosome 19: 42,401,514–42,427,388 (GRCh38)
Exons
10 exons across 25.9 kb
Protein
1,076 amino acids
Also known as
HSL
MANE Select transcript
ENST00000244289.9NM_005357.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Lipodystrophy

    • Familial Partial Lipodystrophy

      Includes the LMNA (Dunnigan), PPARG, PLIN1, LIPE, AKT2, CAV1 and PLAAT3 forms, which cause loss of fat from the limbs and buttocks with insulin resistance, diabetes, high triglycerides and fatty liver.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows early screening and treatment of diabetes, triglycerides and liver disease, and in selected cases metreleptin.

How LIPE is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where LIPE sits. LIPE and 27 genes near it on chromosome 19, from 41,914,451 to 42,914,450.Chromosome 1919q13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4342 Mb42.2 Mb42.4 Mb42.6 Mb42.8 MbARHGEF1: 41,883,063–41,930,150, forward strandARHGEF1ERFL: 41,907,704–41,928,449, reverse strandERFLRABAC1: 41,956,681–41,959,390, reverse strandRABAC1: 41,956,879–41,994,232, reverse strandATP1A3: 41,966,582–41,997,497, reverse strandATP1A3GRIK5: 41,998,315–42,070,240, reverse strandGRIK5ZNF574: 42,068,477–42,083,096, forward strandZNF574POU2F2: 42,086,110–42,196,585, reverse strandPOU2F2DEDD2: 42,198,593–42,220,140, reverse strand: 42,215,133–42,232,149, reverse strandZNF526: 42,216,774–42,231,887, forward strandZNF526GSK3A: 42,226,225–42,242,625, reverse strandGSK3A: 42,234,583–42,255,132, reverse strandERF: 42,247,569–42,255,172, reverse strandERFCIC: 42,268,508–42,295,801, forward strandCICPAFAH1B3: 42,297,023–42,303,546, reverse strandPAFAH1B3PRR19: 42,302,098–42,310,821, forward strandPRR19TMEM145: 42,313,299–42,325,064, forward strandTMEM145MEGF8: 42,325,518–42,378,769, forward strandMEGF8CNFN: 42,387,019–42,390,299, reverse strandCNFNLIPE: 42,401,514–42,427,388, reverse strandLIPECXCL17: 42,427,995–42,443,029, reverse strandCXCL17CEACAM1: 42,507,230–42,561,234, reverse strandCEACAM1CEACAM8: 42,580,243–42,595,055, reverse strandCEACAM8PSG3: 42,709,084–42,740,524, reverse strandPSG3PSG8: 42,752,686–42,765,711, reverse strandPSG8PSG1: 42,866,462–42,879,822, reverse strandPSG1PSG6: 42,902,060–42,919,563, reverse strandPSG6Diagram of LIPE: 10 exons on the reverse strand of chromosome 19Exon 7: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 10: 42,401,514–42,402,075, 562 basesExon 9: 42,402,607–42,403,031, 425 basesExon 8: 42,405,385–42,405,561, 177 basesExon 7: 42,406,161–42,406,388, 228 basesExon 6: 42,407,174–42,407,468, 295 basesExon 5: 42,407,606–42,407,791, 186 basesExon 4: 42,407,976–42,408,121, 146 basesExon 3: 42,408,232–42,408,322, 91 basesExon 2: 42,410,307–42,410,842, 536 basesExon 1: 42,426,267–42,427,388, 1,122 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 25.9 kb; 3,231 of those bases code for the protein.

How a genome test reads LIPE

2

positions in LIPE where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 25.9 kb of LIPE, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LIPE gene: lipase E, hormone sensitive type. Retrieved 16 October 2026, from https://dantelabs.com/genes/lipe

Vancouver

Dante Labs. LIPE gene: lipase E, hormone sensitive type [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lipe

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