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Gene

MYL4

myosin light chain 4

Summary

Cytogenetic location
17q21.32
Coordinates
Chromosome 17: 47,209,348–47,223,679 (GRCh38)
Exons
7 exons across 14.3 kb
Protein
197 amino acids
Inheritance
Autosomal dominant
Also known as
ALC1, AMLC, GT1, PRO1957
MANE Select transcript
ENST00000393450.5NM_002476.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Atrial Fibrillation

    • Autosomal dominant

      Atrial fibrillation running in families, linked to changes in genes such as KCNQ1, KCNJ2, GJA5, MYL4, NPPA and SCN5A.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing about it supports earlier ECG checks for relatives and timely discussion of stroke prevention.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How MYL4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 17, with a bracket where MYL4 sits. MYL4 and 13 genes near it on chromosome 17, from 46,716,514 to 47,716,513.Chromosome 1717q21.32p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.346.8 Mb47 Mb47.2 Mb47.4 Mb47.6 MbNSF: 46,590,661–46,757,679, forward strandNSFWNT3: 46,762,493–46,833,154, reverse strandWNT3WNT9B: 46,833,201–46,886,730, forward strandWNT9BGOSR2: 46,923,075–46,975,524, forward strandGOSR2: 46,923,133–47,049,932, forward strandRPRML: 46,978,156–46,979,253, reverse strandRPRMLCDC27: 47,117,703–47,189,422, reverse strandCDC27MYL4: 47,209,348–47,223,679, forward strandMYL4ITGB3: 47,253,649–47,323,218, forward strandITGB3: 47,253,897–47,344,292, forward strandEFCAB13: 47,323,290–47,441,312, forward strandEFCAB13NPEPPS: 47,522,942–47,624,707, forward strandNPEPPSKPNB1: 47,649,476–47,685,505, forward strandKPNB1TBKBP1: 47,694,030–47,712,063, forward strandTBKBP1Diagram of MYL4: 7 exons on the forward strand of chromosome 17Exon 1: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 1: 47,209,348–47,209,557, 210 basesExon 2: 47,213,799–47,213,826, 28 basesExon 3: 47,219,904–47,220,053, 150 basesExon 4: 47,221,682–47,221,855, 174 basesExon 5: 47,222,380–47,222,457, 78 basesExon 6: 47,223,014–47,223,057, 44 basesExon 7: 47,223,509–47,223,679, 171 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 14.3 kb; 594 of those bases code for the protein.

How a genome test reads MYL4

14

positions in MYL4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 14.3 kb of MYL4, introns included, not only the 0.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MYL4 gene: myosin light chain 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/myl4

Vancouver

Dante Labs. MYL4 gene: myosin light chain 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/myl4

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