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Gene

NPPA

natriuretic peptide A

Summary

Cytogenetic location
1p36.22
Coordinates
Chromosome 1: 11,845,709–11,847,783 (GRCh38)
Exons
3 exons across 2.1 kb
Protein
151 amino acids
Previous symbols
ANP, PND
MANE Select transcript
ENST00000376480.7NM_006172.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads NPPA yet. The test sequences your whole genome, so your data includes it all the same.

How NPPA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where NPPA sits. NPPA and 18 genes near it on chromosome 1, from 11,346,746 to 12,346,745.Chromosome 11p36.22p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4411.4 Mb11.6 Mb11.8 Mb12 Mb12.2 MbDISP3: 11,478,905–11,537,583, forward strandDISP3FBXO2: 11,637,018–11,655,785, reverse strandFBXO2FBXO44: 11,650,618–11,663,327, forward strandFBXO44MAD2L2: 11,657,230–11,692,605, reverse strandMAD2L2FBXO6: 11,664,141–11,674,354, forward strandFBXO6DRAXIN: 11,690,958–11,725,857, forward strandDRAXINAGTRAP: 11,736,070–11,754,802, forward strandAGTRAPC1orf167: 11,761,787–11,789,585, forward strandC1orf167MTHFR: 11,785,723–11,806,455, reverse strandMTHFRCLCN6: 11,806,096–11,848,080, forward strandCLCN6NPPA: 11,845,709–11,847,783, reverse strandNPPANPPB: 11,857,454–11,859,648, reverse strandNPPBKIAA2013: 11,919,590–11,926,428, reverse strandKIAA2013PLOD1: 11,934,205–11,975,542, forward strandPLOD1MFN2: 11,980,181–12,015,211, forward strandMFN2MIIP: 12,019,466–12,032,048, forward strandMIIPTNFRSF8: 12,063,079–12,144,221, forward strandTNFRSF8TNFRSF1B: 12,166,970–12,209,228, forward strandTNFRSF1BVPS13D: 12,230,007–12,512,047, forward strandVPS13DDiagram of NPPA: 3 exons on the reverse strand of chromosome 1Exon 2: 1 known disease-causing siteExon 3: 11,845,709–11,846,014, 306 basesExon 2: 11,847,113–11,847,439, 327 basesExon 1: 11,847,562–11,847,783, 222 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 2.1 kb; 456 of those bases code for the protein.

How a genome test reads NPPA

1

position in NPPA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 2.1 kb of NPPA, introns included, not only the 0.9 kb of exons.

Traits linked to NPPA

The Human Phenotype Ontology lists these as features of the rare conditions NPPA can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NPPA gene: natriuretic peptide A. Retrieved 17 October 2026, from https://dantelabs.com/genes/nppa

Vancouver

Dante Labs. NPPA gene: natriuretic peptide A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nppa

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