Gene
MAT2A
methionine adenosyltransferase 2A
- HGNC 6904↗(opens in a new tab)
- Ensembl gene ENSG00000168906↗(opens in a new tab)
- NCBI Gene 4144↗(opens in a new tab)
Summary
- Cytogenetic location
- 2p11.2
- Coordinates
- Chromosome 2: 85,539,168–85,545,281 (GRCh38)
- Exons
- 9 exons across 6.1 kb
- Protein
- 395 amino acids
- Also known as
- SAMS2, MATA2, MATII, MAT-II
- MANE Select transcript
- ENST00000306434.8NM_005911.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How MAT2A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.8 kb of the gene's 6.1 kb; 1,188 of those bases code for the protein.
Traits linked to MAT2A
The Human Phenotype Ontology lists these as features of the rare conditions MAT2A can cause. Each trait's page lists the other genes linked to it.
Abnormality of the cardiovascular system
- Cutis marmorata
- Mucoid extracellular matrix accumulation
- Abnormal left ventricular function
- Aortic regurgitation
- Ascending aortic dissection
- Descending aortic dissection
- Enlarged heart
- High blood pressure
Show 14 more traits
- Plaque build-up in arteries supplying blood to heart
- Abdominal aortic aneurysm
- Aortic valve has two leaflets rather than three
- Brain aneurysm
- Bulge in wall of root of large artery that carries blood away from heart
- Carotid artery dilatation
- Depleted blood volume
- Descending thoracic aorta aneurysm
- Ischemic stroke
- Mini stroke
- Patent ductus arteriosus
- Peripheral arterial stenosis
- Stroke
- Tear in inner wall of large artery that carries blood away from heart
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). MAT2A gene: methionine adenosyltransferase 2A. Retrieved 17 October 2026, from https://dantelabs.com/genes/mat2a
Dante Labs. MAT2A gene: methionine adenosyltransferase 2A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mat2a
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