Trait

Precordial pain

A type of chest pain that arises in the or under the left breast and often described as throbbing, stabbing, or burning, and lasting hours or longer. The pain may arise with or after effort, and may spread to the left arm or left side of the neck.

HPO HP:0032141

Body system: Constitutional symptom

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3 genes linked to Precordial pain

Changes in these genes cause rare conditions in which Precordial pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PNPLA2patatin like domain 2, triacylglycerol lipase	Often (30–79%)	In 1 condition
COL4A5collagen type IV alpha 5 chain	Sometimes (5–29%)	In 1 condition
COL4A6collagen type IV alpha 6 chain	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Chest pain

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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