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Gene

LOX

lysyl oxidase

Summary

Cytogenetic location
5q23.1
Coordinates
Chromosome 5: 122,063,195–122,078,259 (GRCh38)
Exons
7 exons across 15.1 kb
Protein
417 amino acids
Inheritance
Autosomal dominant
MANE Select transcript
ENST00000231004.5NM_002317.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Aortic Aneurysm

    • Familial Thoracic Aortic Aneurysm and DissectionAutosomal dominant

      Inherited widening and tearing of the thoracic aorta, caused by changes in genes such as ACTA2, MYH11, MYLK, LOX, PRKG1, MFAP5 and THSD4.

      • ClinGen rates the link strong
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it supports regular aortic imaging, blood pressure control and timely preventive surgery, and screening of relatives.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How LOX is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 5, with a bracket where LOX sits. LOX and 5 genes near it on chromosome 5, from 121,570,727 to 122,570,726.Chromosome 55q23.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3121.6 Mb121.8 Mb122 Mb122.2 Mb122.4 MbFTMT: 121,851,882–121,852,833, forward strandFTMTSRFBP1: 121,961,956–122,075,858, forward strandSRFBP1LOX: 122,063,195–122,078,259, reverse strandLOXZNF474: 122,129,540–122,184,959, forward strandZNF474ZNF475: 122,129,622–122,184,959, forward strandZNF475SNCAIP: 122,311,354–122,464,224, forward strandSNCAIPDiagram of LOX: 7 exons on the reverse strand of chromosome 5Exon 6: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 1: 6 known disease-causing sitesExon 7: 122,063,195–122,066,749, 3,555 basesExon 6: 122,070,053–122,070,168, 116 basesExon 5: 122,070,494–122,070,589, 96 basesExon 4: 122,074,013–122,074,169, 157 basesExon 3: 122,075,404–122,075,541, 138 basesExon 2: 122,076,893–122,077,001, 109 basesExon 1: 122,077,355–122,078,259, 905 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 15.1 kb; 1,254 of those bases code for the protein.

How a genome test reads LOX

19

positions in LOX where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.1 kb of LOX, introns included, not only the 5.1 kb of exons.

Genes linked to the same conditions

Traits linked to LOX

The Human Phenotype Ontology lists these as features of the rare conditions LOX can cause. Each trait's page lists the other genes linked to it.

Abnormality of the cardiovascular system

Show 20 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LOX gene: lysyl oxidase. Retrieved 17 October 2026, from https://dantelabs.com/genes/lox

Vancouver

Dante Labs. LOX gene: lysyl oxidase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lox

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