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Gene

GPX4

glutathione peroxidase 4

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 1,103,994–1,106,779 (GRCh38)
Exons
7 exons across 2.8 kb
Protein
197 amino acids
Also known as
PHGPx, MCSP
MANE Select transcript
ENST00000354171.13NM_002085.5
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads GPX4 yet. The test sequences your whole genome, so your data includes it all the same.

How GPX4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where GPX4 sits. GPX4 and 49 genes near it on chromosome 19, from 605,387 to 1,605,386.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.430.8 Mb1 Mb1.2 Mb1.4 Mb1.6 MbHCN2: 589,881–617,159, forward strandHCN2POLRMT: 617,168–633,619, reverse strandPOLRMTFGF22: 639,879–644,373, forward strandFGF22RNF126: 647,526–663,336, reverse strandRNF126FSTL3: 676,366–683,793, forward strandFSTL3PRSS57: 685,546–695,498, reverse strandPRSS57PALM: 708,906–748,329, forward strandPALMMISP: 748,404–764,363, forward strandMISPPTBP1: 797,075–812,327, forward strandPLPPR3: 810,908–822,619, reverse strandAZU1: 825,097–832,018, forward strandAZU1PRTN3: 840,999–848,255, forward strandPRTN3ELANE: 850,951–856,247, forward strandELANECFD: 859,426–869,492, forward strandCFDMED16: 867,630–893,222, reverse strandMED16R3HDM4: 896,503–913,245, reverse strandR3HDM4KISS1R: 917,287–921,005, forward strandKISS1RARID3A: 924,528–975,939, forward strandARID3AWDR18: 984,248–998,438, forward strandWDR18GRIN3B: 1,000,419–1,009,732, forward strandGRIN3BTMEM259: 1,009,615–1,021,270, reverse strandTMEM259CNN2: 1,026,270–1,039,077, forward strandCNN2ABCA7: 1,039,997–1,065,572, forward strandABCA7ARHGAP45: 1,065,923–1,087,829, forward strandARHGAP45POLR2E: 1,085,104–1,095,486, reverse strandPOLR2EGPX4: 1,103,994–1,106,779, forward strandGPX4SBNO2: 1,107,634–1,174,295, reverse strandSBNO2STK11: 1,177,558–1,228,431, forward strandSTK11CBARP: 1,228,282–1,239,465, reverse strandCBARPATP5F1D: 1,241,734–1,244,828, forward strandATP5F1DMIDN: 1,248,316–1,259,145, forward strandMIDNCIRBP: 1,259,384–1,274,880, forward strandCIRBPFAM174C: 1,275,509–1,279,244, forward strandFAM174C: 1,276,021–1,279,244, forward strandEFNA2: 1,285,873–1,301,431, forward strandPWWP3A: 1,354,293–1,378,434, forward strandPWWP3ANDUFS7: 1,383,527–1,395,590, forward strandNDUFS7GAMT: 1,397,026–1,401,731, reverse strandGAMTDAZAP1: 1,407,533–1,435,687, forward strandDAZAP1RPS15: 1,438,149–1,440,508, forward strandRPS15APC2: 1,446,302–1,473,244, forward strandAPC2C19orf25: 1,461,143–1,479,565, reverse strandC19orf25PCSK4: 1,481,428–1,490,752, reverse strandPCSK4REEP6: 1,491,016–1,497,928, forward strandREEP6ADAMTSL5: 1,503,045–1,513,604, reverse strandPLK5: 1,507,978–1,536,046, forward strandMEX3D: 1,554,672–1,568,352, reverse strandMEX3DMBD3: 1,573,596–1,592,911, reverse strandMBD3: 1,578,339–1,605,445, reverse strandUQCR11: 1,593,987–1,605,500, reverse strandUQCR11Diagram of GPX4: 7 exons on the forward strand of chromosome 19Exon 1: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 1: 1,103,994–1,104,127, 134 basesExon 2: 1,105,186–1,105,280, 95 basesExon 3: 1,105,366–1,105,510, 145 basesExon 4: 1,105,658–1,105,809, 152 basesExon 5: 1,106,242–1,106,266, 25 basesExon 6: 1,106,400–1,106,459, 60 basesExon 7: 1,106,540–1,106,779, 240 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 2.8 kb; 594 of those bases code for the protein.

How a genome test reads GPX4

4

positions in GPX4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 2.8 kb of GPX4, introns included, not only the 0.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPX4 gene: glutathione peroxidase 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/gpx4

Vancouver

Dante Labs. GPX4 gene: glutathione peroxidase 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gpx4

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