Traits

Traits linked to APC

APC regulator of Wnt signaling pathway

The Human Phenotype Ontology links 158 traits to APC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	Hvor ofte den forekommer
Adenomatous colonic polyposis	Alltid
Fundic gland polyposis	Alltid
Abnormality of the abdominal wall	Svært ofte (80–99 %)
Colon cancer	Svært ofte (80–99 %)
Colorectal polyposis	Svært ofte (80–99 %)
Duodenal polyposis	Svært ofte (80–99 %)
Gastrointestinal desmoid tumor	Svært ofte (80–99 %)
Gastrointestinal tract tumor	Svært ofte (80–99 %)
Abdominal pain	Ofte (30–79 %)
Constipation	Ofte (30–79 %)
Diarrhea	Ofte (30–79 %)
Gastric adenocarcinoma	Ofte (30–79 %)
Growths in inner lining of intestine	Ofte (30–79 %)
Large intestinal polyposis	Ofte (30–79 %)
Malabsorption	Ofte (30–79 %)
Multiple gastric polyps	Ofte (30–79 %)
Rectal polyposis	Ofte (30–79 %)
Stomach tumor	Ofte (30–79 %)
Adenocarcinoma of the colon	Noen ganger (5–29 %)
Duodenal adenocarcinoma	Noen ganger (5–29 %)
Intestinal obstruction	Noen ganger (5–29 %)
Adenocarcinoma of the small intestine	Sjelden (1–4%)
Bile duct cancer	Sjelden (1–4%)
Biliary tract obstruction	Sjelden (1–4%)
Cancer of the pancreas	Sjelden (1–4%)
Gastrointestinal carcinoma	Sjelden (1–4%)
Hepatoblastoma	Sjelden (1–4%)
Neoplasm of the gallbladder	Sjelden (1–4%)
Pancreatic adenocarcinoma	Sjelden (1–4%)
Pancreatic inflammation	Sjelden (1–4%)
Stomach cancer	Sjelden (1–4%)
Hepatocellular carcinoma	Ikke registrert
Hereditary nonpolyposis colorectal carcinoma	Ikke registrert
Micronodular cirrhosis	Ikke registrert
Small intestine carcinoid	Ikke registrert
Subacute progressive viral hepatitis	Ikke registrert

Abnormality of head or neck

Trait	Hvor ofte den forekommer
Frontal bossing	Svært ofte (80–99 %)
Abnormal dentition	Ofte (30–79 %)
Abnormality of canine	Ofte (30–79 %)
Big lower jaw	Ofte (30–79 %)
Broad nasal tip	Ofte (30–79 %)
Downward slanting of the opening between the eyelids	Ofte (30–79 %)
Full upper lip	Ofte (30–79 %)
High forehead	Ofte (30–79 %)
High palate	Ofte (30–79 %)
Long face	Ofte (30–79 %)
Long philtrum	Ofte (30–79 %)
Narrow mouth	Ofte (30–79 %)
Relatively large head	Ofte (30–79 %)
Abnormal cementum morphology	Noen ganger (5–29 %)
Abnormal tooth enamel	Noen ganger (5–29 %)
Beaked nose	Noen ganger (5–29 %)
Dental cavities	Noen ganger (5–29 %)
Everted eyelid	Noen ganger (5–29 %)
Extra teeth	Noen ganger (5–29 %)
Failure of development of between one and six teeth	Noen ganger (5–29 %)
Failure of eruption of tooth	Noen ganger (5–29 %)
High, narrow palate	Noen ganger (5–29 %)
Little lower jaw	Noen ganger (5–29 %)
Low hairline at back of neck	Noen ganger (5–29 %)
Odontoma	Noen ganger (5–29 %)
Short neck	Noen ganger (5–29 %)
Short nose	Noen ganger (5–29 %)
Short philtrum	Noen ganger (5–29 %)
Zygomatic flattening	Noen ganger (5–29 %)

Abnormality of limbs

Trait	Hvor ofte den forekommer
Abnormal shape of long bones of hand	Svært ofte (80–99 %)
Finger syndactyly	Svært ofte (80–99 %)
Fusion of wrist bones	Svært ofte (80–99 %)
Oligodactyly	Svært ofte (80–99 %)
Fused forearm bones	Ofte (30–79 %)
Fused toes	Ofte (30–79 %)
Short thumb	Ofte (30–79 %)
Underdeveloped inner large forearm bone	Ofte (30–79 %)
Underdeveloped outer large forearm bone	Ofte (30–79 %)
Elbow dislocation	Noen ganger (5–29 %)
Hip dislocation	Noen ganger (5–29 %)
Missing toes	Noen ganger (5–29 %)
Single transverse palmar crease	Noen ganger (5–29 %)
Smaller or shorter than typical limbs	Noen ganger (5–29 %)

Abnormality of the integument

Trait	Hvor ofte den forekommer
Absent fingernail	Svært ofte (80–99 %)
Firm lump under the skin	Svært ofte (80–99 %)
Absent toenail	Ofte (30–79 %)
Early balding	Ofte (30–79 %)
Epidermoid cyst	Ofte (30–79 %)
Abnormal fingerprints	Noen ganger (5–29 %)
Papilloma	Noen ganger (5–29 %)
Skin cancer	Noen ganger (5–29 %)
Localized skin lesion	Sjelden (1–4%)
Pilomatrixoma	Sjelden (1–4%)
Keloids	Ikke registrert
Patchy darkened skin	Ikke registrert

Abnormality of the musculoskeletal system

Trait	Hvor ofte den forekommer
Fusion of joints	Svært ofte (80–99 %)
Muscular abnormality	Svært ofte (80–99 %)
Osteoma	Ofte (30–79 %)
Abnormal vertebral body morphology	Noen ganger (5–29 %)
Abnormality of the ribs	Noen ganger (5–29 %)
Breakdown of bone	Noen ganger (5–29 %)
Generalized decreased muscle tone	Noen ganger (5–29 %)
Limitation of joint mobility	Noen ganger (5–29 %)
Scoliosis	Noen ganger (5–29 %)
Spastic walk	Noen ganger (5–29 %)
Fatty lump	Sjelden (1–4%)
Multiple fatty lumps	Ikke registrert

Abnormality of the endocrine system

Trait	Hvor ofte den forekommer
Thyroid nodule	Ofte (30–79 %)
Abnormality of the thyroid gland	Noen ganger (5–29 %)
Adrenocortical adenoma	Noen ganger (5–29 %)
Neoplasm of the adrenal gland	Noen ganger (5–29 %)
Papillary thyroid carcinoma	Noen ganger (5–29 %)
Thyroid adenoma	Noen ganger (5–29 %)
Underactive thyroid	Noen ganger (5–29 %)
Adrenocortical carcinoma	Sjelden (1–4%)
Enlarged thyroid gland in neck	Sjelden (1–4%)
Noncancerous tumor in pituitary gland	Sjelden (1–4%)
Thyroid gland inflammation	Sjelden (1–4%)

Abnormality of the genitourinary system

Trait	Hvor ofte den forekommer
Abnormality of the upper urinary tract	Noen ganger (5–29 %)
Absent/small kidney	Noen ganger (5–29 %)
Crossed fused renal ectopia	Noen ganger (5–29 %)
Hydronephrosis	Noen ganger (5–29 %)
Multiple kidney cysts	Noen ganger (5–29 %)
Uterine leiomyoma	Noen ganger (5–29 %)
Abnormality of the kidney	Sjelden (1–4%)
Cancer starting in small tubes in kidneys	Ikke registrert
Transitional cell carcinoma of the bladder	Ikke registrert
Uterine leiomyosarcoma	Ikke registrert

Abnormality of the eye

Trait	Hvor ofte den forekommer
Congenital hypertrophy of retinal pigment epithelium	Svært ofte (80–99 %)
Abnormal retinal pigmentation	Ofte (30–79 %)
Wide-set eyes	Ofte (30–79 %)
Bulging eye	Noen ganger (5–29 %)
Clouding of the lens of the eye	Noen ganger (5–29 %)
Drooping upper eyelid	Noen ganger (5–29 %)
Involuntary, rapid, rhythmic eye movements	Noen ganger (5–29 %)
Optic disc hypoplasia	Noen ganger (5–29 %)
Posterior polar cataract	Noen ganger (5–29 %)

Abnormality of the nervous system

Trait	Hvor ofte den forekommer
Intellectual disability, mild	Ofte (30–79 %)
Reading disability	Ofte (30–79 %)
Astrocytoma	Noen ganger (5–29 %)
Brain neoplasm	Sjelden (1–4%)
Ependymoma	Sjelden (1–4%)
Medulloblastoma	Sjelden (1–4%)

Abnormal tissue mass

Trait	Hvor ofte den forekommer
Fibroma	Svært ofte (80–99 %)
Angiofibromas	Noen ganger (5–29 %)
Soft tissue neoplasm	Sjelden (1–4%)
Carcinoma	Ikke registrert

Abnormality of blood and blood-forming tissues

Trait	Hvor ofte den forekommer
Intestinal bleeding	Ofte (30–79 %)
Iron deficiency anemia	Ofte (30–79 %)
Black feces	Noen ganger (5–29 %)
Gastrointestinal bleeding	Noen ganger (5–29 %)

Constitutional symptom

Trait	Hvor ofte den forekommer
Muscle ache	Ofte (30–79 %)
Chest pain	Noen ganger (5–29 %)
Joint pain	Noen ganger (5–29 %)

Abnormality of the breast

Trait	Hvor ofte den forekommer
Breast cancer	Noen ganger (5–29 %)
Fibroadenoma of the breast	Noen ganger (5–29 %)

Abnormality of the ear

Trait	Hvor ofte den forekommer
Hearing impairment	Noen ganger (5–29 %)
Prominent ear	Noen ganger (5–29 %)

Abnormality of the respiratory system

Trait	Hvor ofte den forekommer
Obstructive lung disease	Noen ganger (5–29 %)
Softening of voice box tissue	Noen ganger (5–29 %)

Abnormality of the immune system

Trait	Hvor ofte den forekommer
Infection in blood stream	Noen ganger (5–29 %)

Laboratory abnormality

Trait	Hvor ofte den forekommer
Increased level of L-fucose in urine	Ikke registrert

Hvor ofte dette forekommer hos personer med en av genets tilstander, oppgitt som den hyppigste forekomsten blant dem, slik Human Phenotype Ontology registrerer den. Disse sidene beskriver egenskaper og forskningen bak dem. De er ikke en diagnose, og om symptomer bør du spørre lege eller genetisk rådgiver.

Slik er informasjonen samlet

The Human Phenotype Ontology, release 2026-09-01: the traits linked to APC and how often each is seen. Find out more at hpo.jax.org.

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