Trait
Recurrent pneumonia
An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia.
Summary
- Also called
- Multiple pulmonary infections, Pneumonia, recurrent, Pneumonia, recurrent episodes, Pulmonary infection, Pulmonary infections, pulmonary infections, recurrent, Recurrent pulmonary infections
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test159 genes linked to Recurrent pneumonia
Changes in these genes cause rare conditions in which Recurrent pneumonia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAadenosine deaminase | Always | In 2 conditions |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Always | In 2 conditions |
| B3GALT6beta-1,3-galactosyltransferase 6 | Always | In 1 condition |
| BLNKB cell linker | Always | In 1 condition |
| C3complement C3 | Always | In 1 condition |
| CD247CD247 molecule | Always | In 2 conditions |
| CD3ECD3 epsilon subunit of T-cell receptor complex | Always | In 2 conditions |
| CD79BCD79b molecule | Always | In 1 condition |
| CEBPECCAAT enhancer binding protein epsilon | Always | In 1 condition |
| COPZ1coat protein complex I subunit zeta 1 | Always | In 1 condition |
| CYBBcytochrome b-245 beta chain | Always | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Always | In 1 condition |
| DOT1LDOT1 like histone lysine methyltransferase | Always | In 1 condition |
| DRC1dynein regulatory complex subunit 1 | Always | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Always | In 1 condition |
| FCHO1FCH and mu domain containing endocytic adaptor 1 | Always | In 1 condition |
| FLT3LGfms related receptor tyrosine kinase 3 ligand | Always | In 1 condition |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Always | In 1 condition |
| IGBP1immunoglobulin binding protein 1 | Always | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 2 conditions |
| IL21Rinterleukin 21 receptor | Always | In 1 condition |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 2 conditions |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| LATlinker for activation of T cells | Always | In 1 condition |
| MAN2B2mannosidase alpha class 2B member 2 | Always | In 1 condition |
| MASP2MBL associated serine protease 2 | Always | In 1 condition |
| MEGF10multiple EGF like domains 10 | Always | In 1 condition |
| MOCS3molybdenum cofactor synthesis 3 | Always | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| NME5NME/NM23 family member 5 | Always | In 1 condition |
| ODAD4outer dynein arm docking complex subunit 4 | Always | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Always | In 1 condition |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RELBRELB proto-oncogene, NF-kB subunit | Always | In 1 condition |
Show 119 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RFXAPregulatory factor X associated protein | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SERPINH1serpin family H member 1 | Always | In 1 condition |
| SFTPCsurfactant protein C | Always | In 1 condition |
| SMARCD2SWI/SNF related BAF chromatin remodeling complex subunit D2 | Always | In 1 condition |
| STK36serine/threonine kinase 36 | Always | In 1 condition |
| TM2D3TM2 domain containing 3 | Always | In 1 condition |
| TNFRSF13CTNF receptor superfamily member 13C | Always | In 2 conditions |
| UNC119unc-119 lipid binding chaperone | Always | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Always | In 1 condition |
| BTKBruton tyrosine kinase | Very often (80–99%) | In 2 conditions |
| DNAH11dynein axonemal heavy chain 11 | Very often (80–99%) | In 1 condition |
| NBNnibrin | Very often (80–99%) | In 2 conditions |
| NFKB2nuclear factor kappa B subunit 2 | Very often (80–99%) | In 2 conditions |
| RFX5regulatory factor X5 | Very often (80–99%) | In 1 condition |
| RFXANKregulatory factor X associated ankyrin containing protein | Very often (80–99%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Very often (80–99%) | In 2 conditions |
| ALMS1ALMS1 centrosome and basal body associated protein | Often (30–79%) | In 2 conditions |
| AP3B1adaptor related protein complex 3 subunit beta 1 | Often (30–79%) | In 1 condition |
| ARPC1Bactin related protein 2/3 complex subunit 1B | Often (30–79%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Often (30–79%) | In 1 condition |
| CAVIN1caveolae associated protein 1 | Often (30–79%) | In 1 condition |
| CCDC39coiled-coil domain 39 molecular ruler complex subunit | Often (30–79%) | In 1 condition |
| CCDC40coiled-coil domain 40 molecular ruler complex subunit | Often (30–79%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Often (30–79%) | In 1 condition |
| CLXNcalaxin | Often (30–79%) | In 1 condition |
| CXCR4C-X-C motif chemokine receptor 4 | Often (30–79%) | In 1 condition |
| DOCK2dedicator of cytokinesis 2 | Often (30–79%) | In 1 condition |
| DOCK8dedicator of cytokinesis 8 | Often (30–79%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Often (30–79%) | In 2 conditions |
| FCGR2AFc gamma receptor IIa | Often (30–79%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Often (30–79%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Often (30–79%) | In 1 condition |
| KCNJ6potassium inwardly rectifying channel subfamily J member 6 | Often (30–79%) | In 2 conditions |
| LMNB1lamin B1 | Often (30–79%) | In 1 condition |
| MED25mediator complex subunit 25 | Often (30–79%) | In 2 conditions |
| NFKB1nuclear factor kappa B subunit 1 | Often (30–79%) | In 1 condition |
| ODAD1outer dynein arm docking complex subunit 1 | Often (30–79%) | In 1 condition |
| ODAD2outer dynein arm docking complex subunit 2 | Often (30–79%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Often (30–79%) | In 1 condition |
| RAC2Rac family small GTPase 2 | Often (30–79%) | In 1 condition |
| RNF168ring finger protein 168 | Often (30–79%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 2 conditions |
| SIAH1siah E3 ubiquitin protein ligase 1 | Often (30–79%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| STK4serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 1 condition |
| TCF3transcription factor 3 | Often (30–79%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Often (30–79%) | In 1 condition |
| WDR1WD repeat domain 1 | Often (30–79%) | In 1 condition |
| WDR19WD repeat domain 19 | Often (30–79%) | In 1 condition |
| WDR35WD repeat domain 35 | Often (30–79%) | In 1 condition |
| AASSaminoadipate-semialdehyde synthase | Sometimes (5–29%) | In 1 condition |
| CD27CD27 molecule | Sometimes (5–29%) | In 1 condition |
| CD3DCD3 delta subunit of T-cell receptor complex | Sometimes (5–29%) | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| DNAAF4dynein axonemal assembly factor 4 | Sometimes (5–29%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Sometimes (5–29%) | In 1 condition |
| DSTdystonin | Sometimes (5–29%) | In 1 condition |
| DZIP1LDAZ interacting zinc finger protein 1 like | Sometimes (5–29%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Sometimes (5–29%) | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Sometimes (5–29%) | In 1 condition |
| FBLN5fibulin 5 | Sometimes (5–29%) | In 1 condition |
| FBXW7F-box and WD repeat domain containing 7 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Sometimes (5–29%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Sometimes (5–29%) | In 1 condition |
| JAK3Janus kinase 3 | Sometimes (5–29%) | In 1 condition |
| KPTNkaptin, actin binding protein | Sometimes (5–29%) | In 2 conditions |
| LRBALPS responsive beige-like anchor protein | Sometimes (5–29%) | In 1 condition |
| LTBP1latent transforming growth factor beta binding protein 1 | Sometimes (5–29%) | In 1 condition |
| LTBP4latent transforming growth factor beta binding protein 4 | Sometimes (5–29%) | In 1 condition |
| NDC1NDC1 transmembrane nucleoporin | Sometimes (5–29%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Sometimes (5–29%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Sometimes (5–29%) | In 1 condition |
| PKP1plakophilin 1 | Sometimes (5–29%) | In 1 condition |
| PURApurine rich element binding protein A | Sometimes (5–29%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Sometimes (5–29%) | In 2 conditions |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| RNF125ring finger protein 125 | Sometimes (5–29%) | In 1 condition |
| SLC35C1solute carrier family 35 member C1 | Sometimes (5–29%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Sometimes (5–29%) | In 1 condition |
| SREBF1sterol regulatory element binding transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 1 condition |
| ZBTB7Azinc finger and BTB domain containing 7A | Sometimes (5–29%) | In 1 condition |
| ZNF341zinc finger protein 341 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| IDSiduronate 2-sulfatase | Rarely (1–4%) | In 1 condition |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Rarely (1–4%) | In 2 conditions |
| SETBP1SET binding protein 1 | Rarely (1–4%) | In 1 condition |
| TBCDtubulin folding cofactor D | Rarely (1–4%) | In 1 condition |
| CD19CD19 molecule | Not recorded | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Not recorded | In 1 condition |
| CR2complement C3d receptor 2 | Not recorded | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Not recorded | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Not recorded | In 1 condition |
| DRC4dynein regulatory complex subunit 4 | Not recorded | In 1 condition |
| EGFRepidermal growth factor receptor | Not recorded | In 1 condition |
| FMO3flavin containing dimethylaniline monoxygenase 3 | Not recorded | In 1 condition |
| FOXN1forkhead box N1 | Not recorded | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Not recorded | In 1 condition |
| HYDINHYDIN axonemal central pair apparatus protein | Not recorded | In 1 condition |
| ICOSinducible T cell costimulator | Not recorded | In 2 conditions |
| IGLL1immunoglobulin lambda like polypeptide 1 | Not recorded | In 1 condition |
| LEPleptin | Not recorded | In 1 condition |
| MTHFD1methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | Not recorded | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Not recorded | In 1 condition |
| NCF2neutrophil cytosolic factor 2 | Not recorded | In 1 condition |
| ORC6origin recognition complex subunit 6 | Not recorded | In 1 condition |
| PEPDpeptidase D | Not recorded | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Not recorded | In 1 condition |
| TNFRSF13BTNF receptor superfamily member 13B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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