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Gene

HYDIN

HYDIN axonemal central pair apparatus protein

Summary

Cytogenetic location
16q22.2
Coordinates
Chromosome 16: 70,802,084–71,230,722 (GRCh38)
Exons
86 exons across 428.6 kb
Protein
5,121 amino acids
Inheritance
Autosomal recessive
Also known as
DKFZp434D0513, KIAA1864, PPP1R31, CILD5
MANE Select transcript
ENST00000393567.7NM_001270974.2
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How HYDIN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where HYDIN sits. HYDIN and 18 genes near it on chromosome 16, from 70,373,445 to 71,659,361.Chromosome 1616q22.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.370.4 Mb70.6 Mb70.8 Mb71 Mb71.2 Mb71.4 Mb71.6 MbDDX19A: 70,346,861–70,379,987, forward strandDDX19AST3GAL2: 70,375,977–70,439,263, reverse strandST3GAL2FCSK: 70,454,398–70,480,275, forward strandFCSKCOG4: 70,480,567–70,523,582, reverse strandCOG4SF3B3: 70,523,782–70,577,670, forward strandSF3B3IL34: 70,579,868–70,661,556, forward strandIL34MTSS2: 70,661,204–70,686,086, reverse strandMTSS2VAC14: 70,687,436–70,801,178, reverse strandVAC14HYDIN: 70,802,084–71,230,722, reverse strandHYDINCMTR2: 71,280,073–71,289,715, reverse strandCMTR2CALB2: 71,358,713–71,391,058, forward strandCALB2TLE7: 71,429,980–71,442,054, reverse strandTLE7ZNF23: 71,447,597–71,463,095, reverse strandZNF23: 71,447,600–71,489,311, reverse strandZNF19: 71,464,555–71,565,502, reverse strandZNF19CHST4: 71,525,233–71,541,950, forward strandCHST4TAT: 71,565,660–71,577,096, reverse strandTATMARVELD3: 71,626,150–71,642,114, forward strandMARVELD3PHLPP2: 71,637,834–71,724,701, reverse strandPHLPP2Diagram of HYDIN: 86 exons on the reverse strand of chromosome 16Exon 86: 1 known disease-causing siteExon 82: 1 known disease-causing siteExon 81: 1 known disease-causing siteExon 80: 1 known disease-causing siteExon 77: 1 known disease-causing siteExon 75: 1 known disease-causing siteExon 74: 1 known disease-causing siteExon 72: 1 known disease-causing siteExon 69: 2 known disease-causing sitesExon 66: 1 known disease-causing siteExon 64: 1 known disease-causing siteExon 60: 1 known disease-causing siteExon 56: 1 known disease-causing siteExon 51: 1 known disease-causing siteExon 50: 1 known disease-causing siteExon 48: 1 known disease-causing siteExon 47: 1 known disease-causing siteExon 46: 2 known disease-causing sitesExon 45: 1 known disease-causing siteExon 41: 3 known disease-causing sitesExon 33: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 23: 2 known disease-causing sitesExon 22: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 15: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 12: 3 known disease-causing sitesExon 11: 1 known disease-causing siteExon 9: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 86: 70,802,084–70,808,062, 5,979 basesExon 85: 70,809,783–70,810,007, 225 basesExon 84: 70,818,342–70,818,572, 231 basesExon 83: 70,827,261–70,827,411, 151 basesExon 82: 70,828,266–70,828,429, 164 basesExon 81: 70,829,618–70,829,830, 213 basesExon 80: 70,832,848–70,833,067, 220 basesExon 79: 70,833,887–70,834,164, 278 basesExon 78: 70,835,676–70,835,834, 159 basesExon 77: 70,837,690–70,837,888, 199 basesExon 76: 70,840,064–70,840,233, 170 basesExon 75: 70,849,726–70,849,947, 222 basesExon 74: 70,850,448–70,850,655, 208 basesExon 73: 70,855,128–70,855,275, 148 basesExon 72: 70,857,705–70,857,870, 166 basesExon 71: 70,860,068–70,860,206, 139 basesExon 70: 70,860,689–70,860,901, 213 basesExon 69: 70,862,048–70,862,255, 208 basesExon 68: 70,863,085–70,863,182, 98 basesExon 67: 70,866,169–70,866,329, 161 basesExon 66: 70,868,570–70,868,788, 219 basesExon 65: 70,872,037–70,872,179, 143 basesExon 64: 70,874,305–70,874,592, 288 basesExon 63: 70,874,817–70,874,919, 103 basesExon 62: 70,879,297–70,879,486, 190 basesExon 61: 70,879,605–70,879,756, 152 basesExon 60: 70,882,660–70,882,895, 236 basesExon 59: 70,883,920–70,884,124, 205 basesExon 58: 70,889,587–70,889,704, 118 basesExon 57: 70,891,646–70,891,884, 239 basesExon 56: 70,892,361–70,892,529, 169 basesExon 55: 70,894,449–70,894,548, 100 basesExon 54: 70,895,981–70,896,080, 100 basesExon 53: 70,901,004–70,901,202, 199 basesExon 52: 70,903,625–70,903,797, 173 basesExon 51: 70,903,905–70,904,064, 160 basesExon 50: 70,907,372–70,907,491, 120 basesExon 49: 70,908,252–70,908,434, 183 basesExon 48: 70,908,653–70,908,861, 209 basesExon 47: 70,918,211–70,918,429, 219 basesExon 46: 70,920,591–70,921,217, 627 basesExon 45: 70,935,952–70,936,114, 163 basesExon 44: 70,938,614–70,938,755, 142 basesExon 43: 70,941,636–70,941,819, 184 basesExon 42: 70,943,812–70,943,949, 138 basesExon 41: 70,952,421–70,952,635, 215 basesExon 40: 70,955,375–70,955,548, 174 basesExon 39: 70,959,647–70,959,820, 174 basesExon 38: 70,961,959–70,962,138, 180 basesExon 37: 70,964,728–70,964,896, 169 basesExon 36: 70,970,520–70,970,759, 240 basesExon 35: 70,973,343–70,973,492, 150 basesExon 34: 70,973,829–70,974,020, 192 basesExon 33: 70,974,173–70,974,300, 128 basesExon 32: 70,974,534–70,974,670, 137 basesExon 31: 70,975,136–70,975,269, 134 basesExon 30: 70,978,914–70,979,041, 128 basesExon 29: 70,981,391–70,981,568, 178 basesExon 28: 70,985,185–70,985,322, 138 basesExon 27: 70,987,924–70,988,133, 210 basesExon 26: 70,988,393–70,988,512, 120 basesExon 25: 70,991,318–70,991,396, 79 basesExon 24: 70,992,070–70,992,210, 141 basesExon 23: 71,018,129–71,018,442, 314 basesExon 22: 71,020,174–71,020,317, 144 basesExon 21: 71,025,383–71,025,526, 144 basesExon 20: 71,027,602–71,027,875, 274 basesExon 19: 71,031,679–71,031,917, 239 basesExon 18: 71,060,504–71,060,656, 153 basesExon 17: 71,062,169–71,062,333, 165 basesExon 16: 71,064,705–71,064,840, 136 basesExon 15: 71,067,290–71,067,390, 101 basesExon 14: 71,069,267–71,069,502, 236 basesExon 13: 71,079,885–71,079,952, 68 basesExon 12: 71,088,301–71,088,524, 224 basesExon 11: 71,093,817–71,093,935, 119 basesExon 10: 71,115,696–71,115,795, 100 basesExon 9: 71,129,640–71,129,823, 184 basesExon 8: 71,137,151–71,137,352, 202 basesExon 7: 71,152,659–71,152,783, 125 basesExon 6: 71,162,531–71,162,730, 200 basesExon 5: 71,175,607–71,175,741, 135 basesExon 4: 71,178,928–71,179,047, 120 basesExon 3: 71,184,865–71,184,990, 126 basesExon 2: 71,186,761–71,186,918, 158 basesExon 1: 71,230,562–71,230,722, 161 bases86807060504030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 21 kb of the gene's 428.6 kb; 15,366 of those bases code for the protein.

How a genome test reads HYDIN

62

positions in HYDIN where ClinVar classes a change as pathogenic or likely pathogenic

59 of them (95%) fall in regions short reads find hard.

  • Low mappability (57 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (59 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 428.6 kb of HYDIN, introns included, not only the 21 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HYDIN gene: HYDIN axonemal central pair apparatus protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/hydin

Vancouver

Dante Labs. HYDIN gene: HYDIN axonemal central pair apparatus protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hydin

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