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Gene

DOCK8

dedicator of cytokinesis 8

Summary

Cytogenetic location
9p24.3
Coordinates
Chromosome 9: 214,865–465,255 (GRCh38)
Exons
48 exons across 250.4 kb
Protein
2,099 amino acids
Also known as
FLJ00026, FLJ00152, ZIR8, FLJ00346
MANE Select transcript
ENST00000432829.7NM_203447.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hyper-IgE Syndrome

    • A condition that is characterized by elevated serum IgE, dermatitis, and respiratory infections.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How DOCK8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where DOCK8 sits. DOCK8 and 4 genes near it on chromosome 9, from 1 to 840,059.Chromosome 99p24.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.30.1 Mb0.2 Mb0.3 Mb0.4 Mb0.5 Mb0.6 Mb0.7 Mb0.8 MbWASHC1: 14,469–73,865, reverse strandWASHC1FOXD4: 116,231–118,417, reverse strandFOXD4ZNG1A: 119,288–179,147, reverse strandZNG1ADOCK8: 214,865–465,255, forward strandDOCK8KANK1: 470,289–746,105, forward strandKANK1Diagram of DOCK8: 48 exons on the forward strand of chromosome 9Exon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 11: 3 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 13: 4 known disease-causing sitesExon 14: 4 known disease-causing sitesExon 15: 1 known disease-causing siteExon 17: 3 known disease-causing sitesExon 18: 1 known disease-causing siteExon 21: 2 known disease-causing sitesExon 23: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 26: 2 known disease-causing sitesExon 27: 3 known disease-causing sitesExon 28: 1 known disease-causing siteExon 29: 4 known disease-causing sitesExon 30: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 33: 4 known disease-causing sitesExon 34: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 39: 3 known disease-causing sitesExon 40: 3 known disease-causing sitesExon 41: 2 known disease-causing sitesExon 42: 5 known disease-causing sitesExon 43: 2 known disease-causing sitesExon 44: 1 known disease-causing siteExon 46: 2 known disease-causing sitesExon 47: 1 known disease-causing siteExon 1: 214,865–215,029, 165 basesExon 2: 271,627–271,729, 103 basesExon 3: 286,461–286,636, 176 basesExon 4: 289,510–289,581, 72 basesExon 5: 304,581–304,704, 124 basesExon 6: 311,954–312,166, 213 basesExon 7: 317,043–317,128, 86 basesExon 8: 325,671–325,737, 67 basesExon 9: 328,022–328,171, 150 basesExon 10: 332,398–332,478, 81 basesExon 11: 334,225–334,384, 160 basesExon 12: 336,582–336,718, 137 basesExon 13: 339,006–339,099, 94 basesExon 14: 340,159–340,321, 163 basesExon 15: 368,018–368,135, 118 basesExon 16: 370,230–370,300, 71 basesExon 17: 371,428–371,566, 139 basesExon 18: 372,185–372,286, 102 basesExon 19: 376,210–376,305, 96 basesExon 20: 376,977–377,211, 235 basesExon 21: 379,771–379,935, 165 basesExon 22: 382,513–382,685, 173 basesExon 23: 386,331–386,426, 96 basesExon 24: 390,471–390,566, 96 basesExon 25: 396,785–396,934, 150 basesExon 26: 399,146–399,259, 114 basesExon 27: 404,918–405,073, 156 basesExon 28: 406,930–407,069, 140 basesExon 29: 414,782–414,951, 170 basesExon 30: 418,068–418,207, 140 basesExon 31: 420,401–420,583, 183 basesExon 32: 420,949–421,078, 130 basesExon 33: 422,048–422,135, 88 basesExon 34: 426,885–426,981, 97 basesExon 35: 428,362–428,496, 135 basesExon 36: 429,702–429,854, 153 basesExon 37: 432,166–432,324, 159 basesExon 38: 433,875–433,975, 101 basesExon 39: 434,783–434,975, 193 basesExon 40: 439,245–439,388, 144 basesExon 41: 441,286–441,417, 132 basesExon 42: 441,875–442,009, 135 basesExon 43: 443,427–443,516, 90 basesExon 44: 446,370–446,606, 237 basesExon 45: 449,784–449,927, 144 basesExon 46: 452,011–452,117, 107 basesExon 47: 463,517–463,687, 171 basesExon 48: 464,159–465,255, 1,097 bases151015202530354045485′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.4 kb of the gene's 250.4 kb; 6,300 of those bases code for the protein.

How a genome test reads DOCK8

98

positions in DOCK8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 250.4 kb of DOCK8, introns included, not only the 7.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DOCK8 gene: dedicator of cytokinesis 8. Retrieved 16 October 2026, from https://dantelabs.com/genes/dock8

Vancouver

Dante Labs. DOCK8 gene: dedicator of cytokinesis 8 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dock8

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