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Gene

ODAD2

outer dynein arm docking complex subunit 2

Summary

Cytogenetic location
10p12.1
Coordinates
Chromosome 10: 27,812,168–27,999,079 (GRCh38)
Exons
20 exons across 186.9 kb
Protein
1,044 amino acids
Also known as
FLJ10817, FLJ10376, DKFZP434P1735, CILD23, gudu
Previous symbols
ARMC4
MANE Select transcript
ENST00000305242.10NM_018076.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How ODAD2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where ODAD2 sits. ODAD2 and 4 genes near it on chromosome 10, from 27,405,624 to 28,405,623.Chromosome 1010p12.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.327.6 Mb27.8 Mb28 Mb28.2 Mb28.4 MbPTCHD3: 27,397,121–27,414,368, reverse strandPTCHD3RAB18: 27,504,174–27,545,117, forward strandRAB18MKX: 27,672,874–27,746,394, reverse strandMKXODAD2: 27,812,168–27,999,079, reverse strandODAD2MPP7: 28,050,993–28,335,290, reverse strandMPP7Diagram of ODAD2: 20 exons on the reverse strand of chromosome 10Exon 20: 1 known disease-causing siteExon 19: 4 known disease-causing sitesExon 18: 5 known disease-causing sitesExon 16: 4 known disease-causing sitesExon 15: 3 known disease-causing sitesExon 14: 3 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 11: 3 known disease-causing sitesExon 10: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 20: 27,812,168–27,812,625, 458 basesExon 19: 27,860,625–27,860,846, 222 basesExon 18: 27,862,434–27,862,622, 189 basesExon 17: 27,907,663–27,907,777, 115 basesExon 16: 27,935,010–27,935,252, 243 basesExon 15: 27,936,726–27,936,880, 155 basesExon 14: 27,939,897–27,940,007, 111 basesExon 13: 27,940,563–27,940,805, 243 basesExon 12: 27,944,222–27,944,431, 210 basesExon 11: 27,944,816–27,944,962, 147 basesExon 10: 27,961,568–27,961,715, 148 basesExon 9: 27,968,923–27,969,018, 96 basesExon 8: 27,971,108–27,971,313, 206 basesExon 7: 27,981,466–27,981,582, 117 basesExon 6: 27,983,843–27,983,979, 137 basesExon 5: 27,984,184–27,984,290, 107 basesExon 4: 27,985,019–27,985,211, 193 basesExon 3: 27,987,386–27,987,543, 158 basesExon 2: 27,994,919–27,995,180, 262 basesExon 1: 27,998,994–27,999,079, 86 bases201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 186.9 kb; 3,135 of those bases code for the protein.

Sequencing ODAD2

62

positions in ODAD2 where ClinVar classes a change as pathogenic or likely pathogenic

25 of them (40%) fall in regions short reads find hard.

  • Low mappability (2 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (25 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 186.9 kb of ODAD2, introns included, not only the 3.6 kb of exons.

Genes linked to the same conditions

Traits linked to ODAD2

The Human Phenotype Ontology lists these as features of the rare conditions ODAD2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). ODAD2 gene: outer dynein arm docking complex subunit 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/odad2

Vancouver

Dante Labs. ODAD2 gene: outer dynein arm docking complex subunit 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/odad2

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