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Gene

DOCK11

dedicator of cytokinesis 11

Summary

Cytogenetic location
Xq24
Coordinates
Chromosome X: 118,495,815–118,686,147 (GRCh38)
Exons
53 exons across 190.3 kb
Protein
2,073 amino acids
Also known as
FLJ32122, FLJ43653, ZIZ2, ACG
MANE Select transcript
ENST00000276202.9NM_144658.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • DOCK11-related immune dysregulationX-linked recessive

      Early-onset autoimmunity, low platelets and gut inflammation in males, caused by variants in DOCK11.

      • ClinGen rates the link strong
      • 2 GenCC submitters rate it definitive or strong

How DOCK11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where DOCK11 sits. DOCK11 and 8 genes near it on chromosome X, from 118,090,981 to 119,090,980.Chromosome XXq24p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28118.2 Mb118.4 Mb118.6 Mb118.8 Mb119 MbKLHL13: 117,897,794–118,117,340, reverse strandKLHL13WDR44: 118,345,968–118,457,616, forward strandWDR44DOCK11: 118,495,815–118,686,147, forward strandDOCK11RBBP8P1: 118,632,375–118,634,616, reverse strandRBBP8P1IL13RA1: 118,727,133–118,805,691, forward strandIL13RA1ZCCHC12: 118,823,779–118,826,982, forward strandZCCHC12LONRF3: 118,974,604–119,022,925, forward strandLONRF3CT47C1: 119,072,967–119,076,768, forward strandCT47C1KIAA1210: 119,078,635–119,150,579, reverse strandKIAA1210Diagram of DOCK11: 53 exons on the forward strand of chromosome XExon 48: 1 known disease-causing siteExon 49: 1 known disease-causing siteExon 1: 118,495,815–118,496,073, 259 basesExon 2: 118,542,725–118,542,841, 117 basesExon 3: 118,542,926–118,543,015, 90 basesExon 4: 118,543,511–118,543,593, 83 basesExon 5: 118,545,323–118,545,392, 70 basesExon 6: 118,546,021–118,546,116, 96 basesExon 7: 118,561,383–118,561,517, 135 basesExon 8: 118,566,005–118,566,182, 178 basesExon 9: 118,566,574–118,566,653, 80 basesExon 10: 118,568,079–118,568,162, 84 basesExon 11: 118,572,323–118,572,463, 141 basesExon 12: 118,573,806–118,574,018, 213 basesExon 13: 118,578,525–118,578,647, 123 basesExon 14: 118,580,097–118,580,179, 83 basesExon 15: 118,584,735–118,584,857, 123 basesExon 16: 118,585,041–118,585,117, 77 basesExon 17: 118,588,137–118,588,321, 185 basesExon 18: 118,588,413–118,588,478, 66 basesExon 19: 118,590,210–118,590,302, 93 basesExon 20: 118,593,214–118,593,337, 124 basesExon 21: 118,597,431–118,597,552, 122 basesExon 22: 118,598,030–118,598,116, 87 basesExon 23: 118,599,139–118,599,228, 90 basesExon 24: 118,605,238–118,605,356, 119 basesExon 25: 118,608,072–118,608,141, 70 basesExon 26: 118,608,231–118,608,356, 126 basesExon 27: 118,609,278–118,609,349, 72 basesExon 28: 118,610,272–118,610,418, 147 basesExon 29: 118,614,692–118,614,775, 84 basesExon 30: 118,615,600–118,615,711, 112 basesExon 31: 118,618,550–118,618,728, 179 basesExon 32: 118,624,539–118,624,655, 117 basesExon 33: 118,627,504–118,627,579, 76 basesExon 34: 118,628,163–118,628,272, 110 basesExon 35: 118,630,379–118,630,490, 112 basesExon 36: 118,636,346–118,636,412, 67 basesExon 37: 118,638,080–118,638,127, 48 basesExon 38: 118,639,435–118,639,577, 143 basesExon 39: 118,641,190–118,641,305, 116 basesExon 40: 118,643,457–118,643,594, 138 basesExon 41: 118,648,945–118,649,127, 183 basesExon 42: 118,651,964–118,652,077, 114 basesExon 43: 118,654,602–118,654,817, 216 basesExon 44: 118,654,904–118,654,961, 58 basesExon 45: 118,662,686–118,662,792, 107 basesExon 46: 118,671,023–118,671,145, 123 basesExon 47: 118,675,936–118,676,049, 114 basesExon 48: 118,676,591–118,676,737, 147 basesExon 49: 118,680,482–118,680,692, 211 basesExon 50: 118,681,058–118,681,248, 191 basesExon 51: 118,681,694–118,681,794, 101 basesExon 52: 118,683,079–118,683,217, 139 basesExon 53: 118,685,688–118,686,147, 460 bases15101520253035404550535′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.7 kb of the gene's 190.3 kb; 6,222 of those bases code for the protein.

Sequencing DOCK11

2

positions in DOCK11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 190.3 kb of DOCK11, introns included, not only the 6.7 kb of exons.

Traits linked to DOCK11

The Human Phenotype Ontology lists these as features of the rare conditions DOCK11 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). DOCK11 gene: dedicator of cytokinesis 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/dock11

Vancouver

Dante Labs. DOCK11 gene: dedicator of cytokinesis 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dock11

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