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Gene

SFTPC

surfactant protein C

Summary

Cytogenetic location
8p21.3
Coordinates
Chromosome 8: 22,161,798–22,164,479 (GRCh38)
Exons
6 exons across 2.7 kb
Protein
191 amino acids
Also known as
SP-C, PSP-C, SMDP2, BRICD6
Previous symbols
SFTP2
MANE Select transcript
ENST00000679463.1NM_001317778.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Surfactant Metabolism Dysfunction

    • Hereditary Pulmonary Alveolar Proteinosis and Surfactant Dysfunction

      Inherited disorders of surfactant production or clearance, including those caused by SFTPB, SFTPC, ABCA3, CSF2RA, CSF2RB and MARS1, that range from fatal respiratory distress in newborns to interstitial lung disease in children and adults.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing can support earlier diagnosis, specialist respiratory care, consideration of whole-lung lavage or transplant where appropriate, and information for family planning.

How SFTPC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 8, with a bracket where SFTPC sits. SFTPC and 24 genes near it on chromosome 8, from 21,663,139 to 22,663,138.Chromosome 88p21.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.321.8 Mb22 Mb22.2 Mb22.4 Mb22.6 MbGFRA2: 21,690,398–21,812,370, reverse strandGFRA2DOK2: 21,907,461–21,913,960, reverse strandDOK2XPO7: 21,919,545–22,006,585, forward strandXPO7NPM2: 22,024,081–22,036,897, forward strandNPM2FGF17: 22,042,388–22,048,809, forward strandFGF17DMTN: 22,048,995–22,082,527, forward strandDMTNFHIP2B: 22,089,139–22,104,911, forward strandFHIP2BNUDT18: 22,101,008–22,109,444, reverse strandHR: 22,114,042–22,133,393, reverse strandHRURF: 22,130,458–22,131,010, reverse strandHRURFREEP4: 22,138,007–22,141,951, reverse strandREEP4LGI3: 22,146,824–22,157,084, reverse strandLGI3SFTPC: 22,161,798–22,164,479, forward strandSFTPCBMP1: 22,164,899–22,212,326, forward strandBMP1PHYHIP: 22,219,703–22,232,376, reverse strandPHYHIPPOLR3D: 22,245,078–22,254,601, forward strandPOLR3DPIWIL2: 22,275,310–22,358,580, forward strandPIWIL2SLC39A14: 22,366,727–22,434,129, forward strandSLC39A14PPP3CC: 22,440,746–22,544,727, forward strandPPP3CCSORBS3: 22,544,986–22,575,788, forward strandSORBS3PDLIM2: 22,578,058–22,598,025, forward strandPDLIM2: 22,589,274–22,602,084, forward strandC8orf58: 22,599,588–22,604,271, forward strandC8orf58CCAR2: 22,604,629–22,620,964, forward strandBIN3: 22,610,290–22,669,148, reverse strandDiagram of SFTPC: 6 exons on the forward strand of chromosome 8Exon 2: 1 known disease-causing siteExon 3: 3 known disease-causing sitesExon 4: 6 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 1: 22,161,798–22,161,870, 73 basesExon 2: 22,162,574–22,162,732, 159 basesExon 3: 22,163,080–22,163,202, 123 basesExon 4: 22,163,436–22,163,546, 111 basesExon 5: 22,163,901–22,164,059, 159 basesExon 6: 22,164,266–22,164,479, 214 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.8 kb of the gene's 2.7 kb; 576 of those bases code for the protein.

How a genome test reads SFTPC

16

positions in SFTPC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 2.7 kb of SFTPC, introns included, not only the 0.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SFTPC gene: surfactant protein C. Retrieved 16 October 2026, from https://dantelabs.com/genes/sftpc

Vancouver

Dante Labs. SFTPC gene: surfactant protein C [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/sftpc

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