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Gene

DNAH11

dynein axonemal heavy chain 11

Summary

Cytogenetic location
7p15.3
Coordinates
Chromosome 7: 21,543,039–21,901,839 (GRCh38)
Exons
82 exons across 358.8 kb
Protein
4,516 amino acids
Inheritance
Autosomal recessive
Also known as
Dnahc11, DPL11, CILD7, DNAHC11, DNAHBL, DNHBL
MANE Select transcript
ENST00000409508.8NM_001277115.2
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How DNAH11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where DNAH11 sits. DNAH11 and 3 genes near it on chromosome 7, from 21,184,238 to 22,260,640.Chromosome 77p15.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.321.2 Mb21.4 Mb21.6 Mb21.8 Mb22 Mb22.2 MbSP4: 21,428,024–21,514,822, forward strandSP4DNAH11: 21,543,039–21,901,839, forward strandDNAH11CDCA7L: 21,828,570–21,946,219, reverse strandCDCA7LRAPGEF5: 22,117,700–22,357,170, reverse strandRAPGEF5Diagram of DNAH11: 82 exons on the forward strand of chromosome 7Exon 1: 12 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 4: 8 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 8: 5 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 4 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 12: 5 known disease-causing sitesExon 13: 4 known disease-causing sitesExon 14: 11 known disease-causing sitesExon 15: 16 known disease-causing sitesExon 16: 9 known disease-causing sitesExon 17: 6 known disease-causing sitesExon 18: 9 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 20: 2 known disease-causing sitesExon 21: 9 known disease-causing sitesExon 22: 1 known disease-causing siteExon 23: 3 known disease-causing sitesExon 24: 3 known disease-causing sitesExon 25: 7 known disease-causing sitesExon 26: 11 known disease-causing sitesExon 27: 3 known disease-causing sitesExon 28: 3 known disease-causing sitesExon 29: 4 known disease-causing sitesExon 30: 10 known disease-causing sitesExon 31: 2 known disease-causing sitesExon 32: 4 known disease-causing sitesExon 33: 6 known disease-causing sitesExon 34: 5 known disease-causing sitesExon 35: 2 known disease-causing sitesExon 36: 2 known disease-causing sitesExon 37: 2 known disease-causing sitesExon 38: 4 known disease-causing sitesExon 39: 5 known disease-causing sitesExon 40: 4 known disease-causing sitesExon 41: 6 known disease-causing sitesExon 42: 1 known disease-causing siteExon 43: 3 known disease-causing sitesExon 44: 2 known disease-causing sitesExon 45: 4 known disease-causing sitesExon 46: 4 known disease-causing sitesExon 47: 1 known disease-causing siteExon 48: 7 known disease-causing sitesExon 49: 8 known disease-causing sitesExon 50: 1 known disease-causing siteExon 51: 7 known disease-causing sitesExon 52: 5 known disease-causing sitesExon 53: 4 known disease-causing sitesExon 54: 3 known disease-causing sitesExon 55: 1 known disease-causing siteExon 56: 7 known disease-causing sitesExon 57: 7 known disease-causing sitesExon 58: 6 known disease-causing sitesExon 59: 3 known disease-causing sitesExon 60: 5 known disease-causing sitesExon 61: 1 known disease-causing siteExon 62: 5 known disease-causing sitesExon 63: 8 known disease-causing sitesExon 64: 4 known disease-causing sitesExon 65: 2 known disease-causing sitesExon 66: 4 known disease-causing sitesExon 67: 3 known disease-causing sitesExon 68: 9 known disease-causing sitesExon 69: 1 known disease-causing siteExon 70: 4 known disease-causing sitesExon 71: 6 known disease-causing sitesExon 72: 4 known disease-causing sitesExon 73: 1 known disease-causing siteExon 74: 5 known disease-causing sitesExon 75: 7 known disease-causing sitesExon 76: 1 known disease-causing siteExon 77: 5 known disease-causing sitesExon 78: 4 known disease-causing sitesExon 79: 3 known disease-causing sitesExon 80: 6 known disease-causing sitesExon 81: 13 known disease-causing sitesExon 82: 36 known disease-causing sitesExon 1: 21,543,039–21,543,596, 558 basesExon 2: 21,545,006–21,545,149, 144 basesExon 3: 21,558,802–21,558,998, 197 basesExon 4: 21,559,603–21,559,792, 190 basesExon 5: 21,561,071–21,561,170, 100 basesExon 6: 21,564,186–21,564,397, 212 basesExon 7: 21,570,069–21,570,299, 231 basesExon 8: 21,571,806–21,571,973, 168 basesExon 9: 21,581,905–21,582,021, 117 basesExon 10: 21,588,064–21,588,201, 138 basesExon 11: 21,588,512–21,588,636, 125 basesExon 12: 21,589,208–21,589,403, 196 basesExon 13: 21,590,918–21,591,022, 105 basesExon 14: 21,591,185–21,591,577, 393 basesExon 15: 21,599,787–21,600,119, 333 basesExon 16: 21,600,676–21,600,930, 255 basesExon 17: 21,601,010–21,601,179, 170 basesExon 18: 21,601,396–21,601,618, 223 basesExon 19: 21,606,426–21,606,542, 117 basesExon 20: 21,606,647–21,606,733, 87 basesExon 21: 21,615,114–21,615,272, 159 basesExon 22: 21,616,209–21,616,292, 84 basesExon 23: 21,617,619–21,617,777, 159 basesExon 24: 21,619,100–21,619,222, 123 basesExon 25: 21,619,956–21,620,078, 123 basesExon 26: 21,635,871–21,636,095, 225 basesExon 27: 21,637,611–21,637,702, 92 basesExon 28: 21,638,939–21,639,065, 127 basesExon 29: 21,655,832–21,655,981, 150 basesExon 30: 21,658,798–21,659,031, 234 basesExon 31: 21,681,546–21,681,677, 132 basesExon 32: 21,683,784–21,683,944, 161 basesExon 33: 21,687,099–21,687,255, 157 basesExon 34: 21,687,382–21,687,527, 146 basesExon 35: 21,690,765–21,690,881, 117 basesExon 36: 21,698,075–21,698,213, 139 basesExon 37: 21,702,710–21,702,802, 93 basesExon 38: 21,704,434–21,704,628, 195 basesExon 39: 21,705,460–21,705,537, 78 basesExon 40: 21,707,699–21,707,835, 137 basesExon 41: 21,710,553–21,710,703, 151 basesExon 42: 21,711,712–21,711,860, 149 basesExon 43: 21,717,775–21,717,925, 151 basesExon 44: 21,720,725–21,720,856, 132 basesExon 45: 21,725,811–21,725,984, 174 basesExon 46: 21,735,640–21,735,844, 205 basesExon 47: 21,738,701–21,738,866, 166 basesExon 48: 21,739,571–21,739,673, 103 basesExon 49: 21,741,927–21,742,166, 240 basesExon 50: 21,744,438–21,744,599, 162 basesExon 51: 21,744,870–21,745,063, 194 basesExon 52: 21,748,580–21,748,742, 163 basesExon 53: 21,749,678–21,749,801, 124 basesExon 54: 21,750,222–21,750,364, 143 basesExon 55: 21,765,428–21,765,589, 162 basesExon 56: 21,773,766–21,773,999, 234 basesExon 57: 21,778,958–21,779,104, 147 basesExon 58: 21,784,427–21,784,540, 114 basesExon 59: 21,786,624–21,786,767, 144 basesExon 60: 21,787,401–21,787,583, 183 basesExon 61: 21,789,241–21,789,342, 102 basesExon 62: 21,801,137–21,801,275, 139 basesExon 63: 21,807,883–21,808,049, 167 basesExon 64: 21,816,467–21,816,702, 236 basesExon 65: 21,818,217–21,818,339, 123 basesExon 66: 21,842,544–21,842,748, 205 basesExon 67: 21,852,467–21,852,631, 165 basesExon 68: 21,854,315–21,854,455, 141 basesExon 69: 21,861,853–21,862,023, 171 basesExon 70: 21,864,535–21,864,657, 123 basesExon 71: 21,866,470–21,866,663, 194 basesExon 72: 21,867,859–21,868,007, 149 basesExon 73: 21,868,864–21,868,991, 128 basesExon 74: 21,873,274–21,873,501, 228 basesExon 75: 21,880,702–21,880,893, 192 basesExon 76: 21,884,291–21,884,410, 120 basesExon 77: 21,892,425–21,892,667, 243 basesExon 78: 21,894,623–21,894,805, 183 basesExon 79: 21,894,884–21,894,999, 116 basesExon 80: 21,899,336–21,899,448, 113 basesExon 81: 21,899,980–21,900,120, 141 basesExon 82: 21,901,007–21,901,839, 833 bases1255075825′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 14.3 kb of the gene's 358.8 kb; 13,551 of those bases code for the protein.

How a genome test reads DNAH11

552

positions in DNAH11 where ClinVar classes a change as pathogenic or likely pathogenic

38 of them (6.9%) fall in regions short reads find hard.

  • Segmental duplications (38 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 358.8 kb of DNAH11, introns included, not only the 14.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAH11 gene: dynein axonemal heavy chain 11. Retrieved 16 October 2026, from https://dantelabs.com/genes/dnah11

Vancouver

Dante Labs. DNAH11 gene: dynein axonemal heavy chain 11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dnah11

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