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Gene

CLXN

calaxin

Summary

Cytogenetic location
8q11.21
Coordinates
Chromosome 8: 48,723,391–48,735,268 (GRCh38)
Exons
6 exons across 11.9 kb
Protein
211 amino acids
Inheritance
Autosomal recessive
Also known as
FLJ11767, ODAD5
Previous symbols
EFCAB1
MANE Select transcript
ENST00000262103.8NM_024593.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link strong
      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CLXN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 8, with a bracket where CLXN sits. CLXN and 2 genes near it on chromosome 8, from 48,229,330 to 49,229,329.Chromosome 88q11.21p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.348.4 Mb48.6 Mb48.8 Mb49 Mb49.2 MbCLXN: 48,723,391–48,735,268, reverse strandCLXNSNAI2: 48,917,284–48,921,740, reverse strandSNAI2PPDPFL: 49,054,311–49,076,093, forward strandPPDPFLDiagram of CLXN: 6 exons on the reverse strand of chromosome 8Exon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 6: 48,723,391–48,724,801, 1,411 basesExon 5: 48,729,042–48,729,146, 105 basesExon 4: 48,729,720–48,729,871, 152 basesExon 3: 48,730,540–48,730,644, 105 basesExon 2: 48,731,348–48,731,503, 156 basesExon 1: 48,735,094–48,735,268, 175 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 11.9 kb; 636 of those bases code for the protein.

How a genome test reads CLXN

3

positions in CLXN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.9 kb of CLXN, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CLXN gene: calaxin. Retrieved 17 October 2026, from https://dantelabs.com/genes/clxn

Vancouver

Dante Labs. CLXN gene: calaxin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/clxn

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