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Gene

DOCK2

dedicator of cytokinesis 2

Summary

Cytogenetic location
5q35.1
Coordinates
Chromosome 5: 169,637,275–170,083,382 (GRCh38)
Exons
52 exons across 446.1 kb
Protein
1,830 amino acids
Also known as
KIAA0209
MANE Select transcript
ENST00000520908.7NM_004946.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How DOCK2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 5, with a bracket where DOCK2 sits. DOCK2 and 8 genes near it on chromosome 5, from 169,191,167 to 170,529,490.Chromosome 55q35.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3169.2 Mb169.4 Mb169.6 Mb169.8 Mb170 Mb170.2 Mb170.4 MbSLIT3: 168,661,740–169,301,173, reverse strandSLIT3SPDL1: 169,583,632–169,604,780, forward strandSPDL1DOCK2: 169,637,275–170,083,382, forward strandDOCK2INSYN2B: 169,861,303–169,980,507, reverse strandINSYN2BFOXI1: 170,105,893–170,109,734, forward strandFOXI1C5orf58: 170,228,881–170,252,575, forward strandC5orf58LCP2: 170,246,233–170,297,845, reverse strandLCP2KCNIP1: 170,353,487–170,736,632, forward strandKCNIP1KCNMB1: 170,364,749–170,480,428, reverse strandKCNMB1Diagram of DOCK2: 52 exons on the forward strand of chromosome 5Exon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 14: 2 known disease-causing sitesExon 16: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 27: 1 known disease-causing siteExon 33: 1 known disease-causing siteExon 36: 1 known disease-causing siteExon 47: 2 known disease-causing sitesExon 1: 169,637,275–169,637,369, 95 basesExon 2: 169,654,403–169,654,486, 84 basesExon 3: 169,669,288–169,669,328, 41 basesExon 4: 169,670,542–169,670,597, 56 basesExon 5: 169,671,078–169,671,174, 97 basesExon 6: 169,674,297–169,674,445, 149 basesExon 7: 169,681,744–169,681,879, 136 basesExon 8: 169,684,196–169,684,350, 155 basesExon 9: 169,689,252–169,689,333, 82 basesExon 10: 169,695,803–169,695,938, 136 basesExon 11: 169,698,374–169,698,449, 76 basesExon 12: 169,699,382–169,699,458, 77 basesExon 13: 169,700,014–169,700,139, 126 basesExon 14: 169,702,303–169,702,427, 125 basesExon 15: 169,708,169–169,708,267, 99 basesExon 16: 169,711,935–169,712,007, 73 basesExon 17: 169,712,120–169,712,223, 104 basesExon 18: 169,714,028–169,714,211, 184 basesExon 19: 169,714,360–169,714,457, 98 basesExon 20: 169,716,213–169,716,302, 90 basesExon 21: 169,717,384–169,717,484, 101 basesExon 22: 169,718,657–169,718,791, 135 basesExon 23: 169,747,396–169,747,504, 109 basesExon 24: 169,759,705–169,759,775, 71 basesExon 25: 169,761,519–169,761,625, 107 basesExon 26: 169,803,058–169,803,206, 149 basesExon 27: 169,840,757–169,840,852, 96 basesExon 28: 169,983,068–169,983,166, 99 basesExon 29: 169,985,828–169,985,922, 95 basesExon 30: 169,996,086–169,996,164, 79 basesExon 31: 170,008,497–170,008,597, 101 basesExon 32: 170,008,688–170,008,746, 59 basesExon 33: 170,018,960–170,019,108, 149 basesExon 34: 170,027,863–170,027,948, 86 basesExon 35: 170,034,399–170,034,555, 157 basesExon 36: 170,036,515–170,036,555, 41 basesExon 37: 170,041,055–170,041,145, 91 basesExon 38: 170,042,013–170,042,132, 120 basesExon 39: 170,045,816–170,045,905, 90 basesExon 40: 170,047,510–170,047,614, 105 basesExon 41: 170,050,256–170,050,397, 142 basesExon 42: 170,055,305–170,055,386, 82 basesExon 43: 170,056,684–170,056,768, 85 basesExon 44: 170,057,580–170,057,666, 87 basesExon 45: 170,067,510–170,067,686, 177 basesExon 46: 170,069,137–170,069,220, 84 basesExon 47: 170,075,947–170,076,084, 138 basesExon 48: 170,077,710–170,077,837, 128 basesExon 49: 170,078,975–170,079,146, 172 basesExon 50: 170,080,163–170,080,283, 121 basesExon 51: 170,081,842–170,081,984, 143 basesExon 52: 170,082,796–170,083,382, 587 bases12040525′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.1 kb of the gene's 446.1 kb; 5,493 of those bases code for the protein.

    How a genome test reads DOCK2

    25

    positions in DOCK2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 446.1 kb of DOCK2, introns included, not only the 6.1 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). DOCK2 gene: dedicator of cytokinesis 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/dock2

    Vancouver

    Dante Labs. DOCK2 gene: dedicator of cytokinesis 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dock2

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