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Gene

CENPE

centromere protein E

Summary

Cytogenetic location
4q24
Coordinates
Chromosome 4: 103,105,811–103,198,343 (GRCh38)
Exons
49 exons across 92.5 kb
Protein
2,701 amino acids
Also known as
KIF10, PPP1R61
MANE Select transcript
ENST00000265148.9NM_001813.3
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CENPE yet. The test sequences your whole genome, so your data includes it all the same.

How CENPE is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where CENPE sits. CENPE and 7 genes near it on chromosome 4, from 102,652,077 to 103,652,076.Chromosome 44q24p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2102.8 Mb103 Mb103.2 Mb103.4 Mb103.6 MbMANBA: 102,630,770–102,761,000, reverse strandMANBAUBE2D3: 102,793,516–102,869,287, reverse strandUBE2D3CISD2: 102,868,738–102,903,259, forward strandCISD2SLC9B1: 102,870,501–103,019,793, reverse strandSLC9B1SLC9B2: 103,019,868–103,085,829, reverse strandSLC9B2BDH2: 103,077,592–103,099,885, reverse strandBDH2CENPE: 103,105,811–103,198,343, reverse strandCENPETACR3: 103,585,817–103,719,986, reverse strandTACR3Diagram of CENPE: 49 exons on the reverse strand of chromosome 4Exon 24: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 49: 103,105,811–103,106,316, 506 basesExon 48: 103,108,803–103,109,089, 287 basesExon 47: 103,110,828–103,111,011, 184 basesExon 46: 103,114,455–103,114,552, 98 basesExon 45: 103,116,577–103,116,689, 113 basesExon 44: 103,120,148–103,120,333, 186 basesExon 43: 103,122,871–103,123,089, 219 basesExon 42: 103,132,693–103,132,896, 204 basesExon 41: 103,133,695–103,133,892, 198 basesExon 40: 103,136,141–103,136,359, 219 basesExon 39: 103,138,351–103,138,449, 99 basesExon 38: 103,139,789–103,140,079, 291 basesExon 37: 103,140,256–103,140,414, 159 basesExon 36: 103,140,814–103,141,104, 291 basesExon 35: 103,141,750–103,141,908, 159 basesExon 34: 103,143,248–103,143,406, 159 basesExon 33: 103,144,331–103,144,618, 288 basesExon 32: 103,145,050–103,145,334, 285 basesExon 31: 103,145,523–103,145,681, 159 basesExon 30: 103,145,829–103,146,107, 279 basesExon 29: 103,147,356–103,147,646, 291 basesExon 28: 103,148,844–103,148,999, 156 basesExon 27: 103,149,118–103,149,408, 291 basesExon 26: 103,151,219–103,151,377, 159 basesExon 25: 103,153,047–103,153,250, 204 basesExon 24: 103,158,300–103,158,458, 159 basesExon 23: 103,158,614–103,158,886, 273 basesExon 22: 103,159,010–103,159,324, 315 basesExon 21: 103,160,625–103,160,779, 155 basesExon 20: 103,161,086–103,161,251, 166 basesExon 19: 103,161,335–103,161,457, 123 basesExon 18: 103,163,137–103,163,256, 120 basesExon 17: 103,163,479–103,163,553, 75 basesExon 16: 103,174,736–103,174,903, 168 basesExon 15: 103,175,960–103,176,048, 89 basesExon 14: 103,176,899–103,177,046, 148 basesExon 13: 103,180,311–103,180,469, 159 basesExon 12: 103,181,337–103,181,456, 120 basesExon 11: 103,182,762–103,182,891, 130 basesExon 10: 103,183,201–103,183,288, 88 basesExon 9: 103,185,810–103,185,861, 52 basesExon 8: 103,194,229–103,194,294, 66 basesExon 7: 103,194,374–103,194,441, 68 basesExon 6: 103,194,603–103,194,684, 82 basesExon 5: 103,195,114–103,195,233, 120 basesExon 4: 103,195,920–103,196,038, 119 basesExon 3: 103,196,163–103,196,252, 90 basesExon 2: 103,196,759–103,196,850, 92 basesExon 1: 103,198,264–103,198,343, 80 bases494540353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.5 kb of the gene's 92.5 kb; 8,106 of those bases code for the protein.

How a genome test reads CENPE

5

positions in CENPE where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 92.5 kb of CENPE, introns included, not only the 8.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CENPE gene: centromere protein E. Retrieved 17 October 2026, from https://dantelabs.com/genes/cenpe

Vancouver

Dante Labs. CENPE gene: centromere protein E [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cenpe

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