Gene
TANGO2
transport and golgi organization 2 homolog
- HGNC 25439↗(opens in a new tab)
- Ensembl gene ENSG00000183597↗(opens in a new tab)
- NCBI Gene 128989↗(opens in a new tab)
Summary
- Cytogenetic location
- 22q11.21
- Coordinates
- Chromosome 22: 20,021,110–20,067,164 (GRCh38)
- Exons
- 9 exons across 46.1 kb
- Protein
- 276 amino acids
- Also known as
- DKFZp761P1121
- Previous symbols
- C22orf25
- MANE Select transcript
- ENST00000327374.9NM_152906.7
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How TANGO2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.5 kb of the gene's 46.1 kb; 831 of those bases code for the protein.
How a genome test reads TANGO2
15
positions in TANGO2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 46.1 kb of TANGO2, introns included, not only the 3.5 kb of exons.
Traits linked to TANGO2
The Human Phenotype Ontology lists these as features of the rare conditions TANGO2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Absent speech development
- Ataxia
- Babinski sign
- Brisk reflexes
- Clonus
- Coma
- Difficulty articulating speech
- Global developmental delay
Show 27 more traits
- Intellectual disability
- Loss of developmental milestones
- Motor delay
- Repeated seizures without recovery between them
- Abnormality of extrapyramidal motor function
- Degeneration of cerebrum
- Delayed ability to walk
- Delayed speech and language development
- Epilepsy
- Generalized brain degeneration
- Incoordination
- Involuntary movements
- Moderate global developmental delay
- Dystonia
- Focal impaired awareness seizure
- Generalized myoclonic seizure
- Generalized tonic seizure
- Grand mal seizures
- Increased reflexes
- Infantile spasms
- Mild global developmental delay
- Multifocal seizures
- Severe global developmental delay
- Abnormal gait
- Hyperactive deep tendon reflexes
- Inability to coordinate movements when walking
- Ongoing loss of nerve cells
Laboratory abnormality
- Elevated blood creatine phosphokinase
- Elevated circulating alanine aminotransferase concentration
- Elevated circulating aldolase concentration
- Elevated circulating aspartate aminotransferase concentration
- Metabolic acidosis
- Myoglobinuria
- Elevated circulating tetradecenoylcarnitine concentration
- High blood ammonia levels
Abnormality of the cardiovascular system
- Abnormal EKG
- Abnormal heart rate
- Prolonged QT interval
- Prolonged QTc interval
- Ventricular tachycardia
- Enlarged and thickened heart muscle
- Extra heart beat
- Slow heartbeats
Show 4 more traits
Abnormality of the musculoskeletal system
- Lower limb spasticity
- Breakdown of skeletal muscle
- EMG: myopathic abnormalities
- Acute rhabdomyolysis
- Spastic diplegia
- Spastic tetraplegia
- Spasticity and rigidity of muscles
- Generalized decreased muscle tone
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TANGO2 gene: transport and golgi organization 2 homolog. Retrieved 16 October 2026, from https://dantelabs.com/genes/tango2
Dante Labs. TANGO2 gene: transport and golgi organization 2 homolog [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tango2
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