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Gene

SLC16A1

solute carrier family 16 member 1

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 112,911,847–112,956,196 (GRCh38)
Exons
5 exons across 44.4 kb
Protein
500 amino acids
Inheritance
Autosomal dominant
Also known as
MCT, MCT1
MANE Select transcript
ENST00000369626.8NM_003051.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hyperinsulinism

    • Islet Cell AdenomatosisAutosomal dominant

      A sporadic or inherited disorder characterized by the focal or diffuse proliferation of the cells of the islets of Langerhans in the pancreas. It results in hyperinsulinemia and hypoglycemia.

      • 1 GenCC submitter rates it definitive or strong

    • Abnormally high levels of insulin in the blood.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

Trait report that reads SLC16A1

How SLC16A1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where SLC16A1 sits. SLC16A1 and 11 genes near it on chromosome 1, from 112,434,022 to 113,434,021.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44112.6 Mb112.8 Mb113 Mb113.2 Mb113.4 MbCTTNBP2NL: 112,396,198–112,463,456, forward strandCTTNBP2NLWNT2B: 112,466,541–112,530,165, forward strandWNT2BST7L: 112,523,473–112,620,825, reverse strandST7LCAPZA1: 112,619,173–112,672,747, forward strandCAPZA1MOV10: 112,673,141–112,702,415, forward strandRHOC: 112,699,765–112,707,897, reverse strandRHOC: 112,702,614–112,711,433, reverse strandPPM1J: 112,709,994–112,715,502, reverse strandPPM1JTAFA3: 112,718,881–112,729,076, forward strandTAFA3SLC16A1: 112,911,847–112,956,196, reverse strandSLC16A1LRIG2: 113,073,168–113,132,260, forward strandLRIG2MAGI3: 113,390,390–113,687,431, forward strandMAGI3Diagram of SLC16A1: 5 exons on the reverse strand of chromosome 1Exon 4: 7 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 5: 112,911,847–112,914,165, 2,319 basesExon 4: 112,917,178–112,918,044, 867 basesExon 3: 112,921,990–112,922,133, 144 basesExon 2: 112,929,092–112,929,352, 261 basesExon 1: 112,956,035–112,956,196, 162 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 44.4 kb; 1,503 of those bases code for the protein.

How a genome test reads SLC16A1

11

positions in SLC16A1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 44.4 kb of SLC16A1, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC16A1 gene: solute carrier family 16 member 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/slc16a1

Vancouver

Dante Labs. SLC16A1 gene: solute carrier family 16 member 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/slc16a1

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