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Gene

GPR161

G protein-coupled receptor 161

Summary

Cytogenetic location
1q24.2
Coordinates
Chromosome 1: 168,079,542–168,136,930 (GRCh38)
Exons
6 exons across 57.4 kb
Protein
529 amino acids
Inheritance
Autosomal dominant
Also known as
RE2
MANE Select transcript
ENST00000682931.1NM_001375883.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Medulloblastoma

    • GPR161-related medulloblastoma predispositionAutosomal dominant

      GPR161 variants that predispose to sonic hedgehog-type medulloblastoma in early childhood.

      • ClinGen rates the link strong
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Awareness of neurological symptoms in young children and consideration of brain MRI surveillance.

    • Autosomal dominant
      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How GPR161 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where GPR161 sits. GPR161 and 10 genes near it on chromosome 1, from 167,608,236 to 168,608,235.Chromosome 11q24.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44167.8 Mb168 Mb168.2 Mb168.4 Mb168.6 MbRCSD1: 167,629,660–167,708,706, forward strandRCSD1MPZL1: 167,721,192–167,794,612, forward strandMPZL1ADCY10: 167,809,098–167,914,215, reverse strandADCY10MPC2: 167,916,675–167,937,515, reverse strandMPC2DCAF6: 167,935,783–168,076,846, forward strandDCAF6GPR161: 168,079,542–168,136,930, reverse strandGPR161TIPRL: 168,178,820–168,202,114, forward strandTIPRLSFT2D2: 168,225,938–168,263,172, forward strandSFT2D2TBX19: 168,280,877–168,314,426, forward strandTBX19XCL2: 168,540,765–168,544,113, reverse strandXCL2XCL1: 168,576,596–168,582,069, forward strandXCL1Diagram of GPR161: 6 exons on the reverse strand of chromosome 1Exon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 6: 168,079,542–168,085,796, 6,255 basesExon 5: 168,087,585–168,087,704, 120 basesExon 4: 168,090,564–168,090,668, 105 basesExon 3: 168,096,508–168,097,232, 725 basesExon 2: 168,104,477–168,104,894, 418 basesExon 1: 168,136,739–168,136,930, 192 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.8 kb of the gene's 57.4 kb; 1,590 of those bases code for the protein.

How a genome test reads GPR161

2

positions in GPR161 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 57.4 kb of GPR161, introns included, not only the 7.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPR161 gene: G protein-coupled receptor 161. Retrieved 17 October 2026, from https://dantelabs.com/genes/gpr161

Vancouver

Dante Labs. GPR161 gene: G protein-coupled receptor 161 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gpr161

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