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Gene

SERAC1

serine active site containing 1

Summary

Cytogenetic location
6q25.3
Coordinates
Chromosome 6: 158,109,519–158,168,262 (GRCh38)
Exons
17 exons across 58.7 kb
Protein
654 amino acids
Also known as
FLJ14917
MANE Select transcript
ENST00000647468.2NM_032861.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Leigh Syndrome

      • One of 69 genes linked to it

        A progressive neurological disease defined by specific neuropathological features associating brainstem and basal ganglia lesions.

        • ClinGen rates the link definitive
        • 1 GenCC submitter rates it definitive or strong

    How SERAC1 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 6, with a bracket where SERAC1 sits. SERAC1 and 7 genes near it on chromosome 6, from 157,638,891 to 158,638,890.Chromosome 66q25.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27157.8 Mb158 Mb158.2 Mb158.4 Mb158.6 MbZDHHC14: 157,381,133–157,678,157, forward strandZDHHC14SNX9: 157,700,387–157,945,077, forward strandSNX9SYNJ2: 157,981,824–158,099,176, forward strandSYNJ2SERAC1: 158,109,519–158,168,262, reverse strandSERAC1GTF2H5: 158,167,749–158,199,344, forward strandGTF2H5TULP4: 158,232,236–158,511,828, forward strandTULP4TMEM181: 158,536,436–158,635,519, forward strandTMEM181DYNLT1: 158,612,721–158,644,771, reverse strandDYNLT1Diagram of SERAC1: 17 exons on the reverse strand of chromosome 6Exon 16: 3 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 13: 2 known disease-causing sitesExon 12: 5 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 4 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 17: 158,109,519–158,111,502, 1,984 basesExon 16: 158,113,449–158,113,592, 144 basesExon 15: 158,114,789–158,114,971, 183 basesExon 14: 158,116,185–158,116,282, 98 basesExon 13: 158,117,727–158,117,821, 95 basesExon 12: 158,119,029–158,119,170, 142 basesExon 11: 158,120,425–158,120,575, 151 basesExon 10: 158,128,108–158,128,270, 163 basesExon 9: 158,130,373–158,130,486, 114 basesExon 8: 158,143,056–158,143,184, 129 basesExon 7: 158,144,299–158,144,420, 122 basesExon 6: 158,146,782–158,146,913, 132 basesExon 5: 158,148,865–158,148,954, 90 basesExon 4: 158,150,453–158,150,589, 137 basesExon 3: 158,155,315–158,155,351, 37 basesExon 2: 158,158,273–158,158,364, 92 basesExon 1: 158,168,140–158,168,262, 123 bases1716141210864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.9 kb of the gene's 58.7 kb; 1,965 of those bases code for the protein.

    How a genome test reads SERAC1

    49

    positions in SERAC1 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 58.7 kb of SERAC1, introns included, not only the 3.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SERAC1 gene: serine active site containing 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/serac1

    Vancouver

    Dante Labs. SERAC1 gene: serine active site containing 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/serac1

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