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Gene

NFS1

NFS1 cysteine desulfurase

Summary

Cytogenetic location
20q11.22
Coordinates
Chromosome 20: 35,668,052–35,699,352 (GRCh38)
Exons
13 exons across 31.3 kb
Protein
457 amino acids
Also known as
NifS, IscS
MANE Select transcript
ENST00000374092.9NM_021100.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Mitochondrial Disease

    • Combined Oxidative Phosphorylation Deficiency

      Disorders, usually caused by nuclear genes involved in mitochondrial protein production, that reduce several respiratory chain complexes at once and often cause severe multisystem disease in childhood.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing can end a diagnostic search and guide surveillance and supportive care.

How NFS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 20, with a bracket where NFS1 sits. NFS1 and 21 genes near it on chromosome 20, from 35,183,702 to 36,183,701.Chromosome 2020q11.22p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3335.2 Mb35.4 Mb35.6 Mb35.8 Mb36 MbPROCR: 35,153,330–35,216,253, forward strandPROCRMMP24OS: 35,201,745–35,278,131, reverse strandMMP24: 35,226,559–35,277,030, forward strandMMP24: 35,267,885–35,280,043, reverse strandEIF6: 35,278,891–35,285,009, reverse strandEIF6SACK1C: 35,285,731–35,292,425, reverse strandSACK1CUQCC1: 35,301,219–35,412,070, reverse strandUQCC1GDF5: 35,433,347–35,454,754, reverse strandGDF5CEP250: 35,455,131–35,519,280, forward strandCEP250C20orf173: 35,523,186–35,529,652, reverse strandC20orf173ERGIC3: 35,542,022–35,557,634, forward strandERGIC3SPAG4: 35,615,594–35,621,613, forward strandSPAG4CPNE1: 35,626,031–35,664,962, reverse strandCPNE1: 35,632,340–35,674,544, reverse strandRBM12: 35,648,925–35,664,956, reverse strandRBM12NFS1: 35,668,052–35,699,352, reverse strandNFS1ROMO1: 35,699,228–35,703,939, forward strandROMO1RBM39: 35,701,347–35,742,312, reverse strandRBM39PHF20: 35,771,947–35,950,385, forward strandPHF20SCAND1: 35,953,617–35,959,472, reverse strandSCAND1CNBD2: 35,954,564–36,030,700, forward strandCNBD2EPB41L1: 36,091,504–36,232,799, forward strandEPB41L1Diagram of NFS1: 13 exons on the reverse strand of chromosome 20Exon 13: 35,668,052–35,669,685, 1,634 basesExon 12: 35,672,755–35,672,844, 90 basesExon 11: 35,673,601–35,673,684, 84 basesExon 10: 35,674,350–35,674,431, 82 basesExon 9: 35,674,512–35,674,617, 106 basesExon 8: 35,675,045–35,675,202, 158 basesExon 7: 35,680,737–35,680,871, 135 basesExon 6: 35,681,888–35,681,981, 94 basesExon 5: 35,690,413–35,690,565, 153 basesExon 4: 35,696,377–35,696,460, 84 basesExon 3: 35,697,684–35,697,800, 117 basesExon 2: 35,698,481–35,698,590, 110 basesExon 1: 35,699,192–35,699,352, 161 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 31.3 kb; 1,374 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NFS1 gene: NFS1 cysteine desulfurase. Retrieved 17 October 2026, from https://dantelabs.com/genes/nfs1

Vancouver

Dante Labs. NFS1 gene: NFS1 cysteine desulfurase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nfs1

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