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Gene

QRSL1

glutaminyl-tRNA amidotransferase subunit QRSL1

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 106,629,578–106,668,417 (GRCh38)
Exons
11 exons across 38.8 kb
Protein
528 amino acids
Also known as
GatA, FLJ10989, FLJ12189, DKFZP564C1278, FLJ13447, GATA
MANE Select transcript
ENST00000369046.8NM_018292.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Primary Mitochondrial Disease

    • Combined Oxidative Phosphorylation Deficiency

      Disorders, usually caused by nuclear genes involved in mitochondrial protein production, that reduce several respiratory chain complexes at once and often cause severe multisystem disease in childhood.

      • 2 GenCC submitters rate it definitive or strong
      Actionability

      Knowing can end a diagnostic search and guide surveillance and supportive care.

How QRSL1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where QRSL1 sits. QRSL1 and 6 genes near it on chromosome 6, from 106,148,998 to 107,148,997.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27106.2 Mb106.4 Mb106.6 Mb106.8 Mb107 MbATG5: 106,045,423–106,326,477, reverse strandATG5CRYBG1: 106,360,563–106,572,017, forward strandCRYBG1RTN4IP1: 106,559,393–106,629,503, reverse strandRTN4IP1QRSL1: 106,629,578–106,668,417, forward strandQRSL1CD24: 106,969,831–106,975,802, reverse strandCD24MTRES1: 107,028,167–107,051,594, forward strandMTRES1BEND3: 107,065,138–107,116,234, reverse strandBEND3Diagram of QRSL1: 11 exons on the forward strand of chromosome 6Exon 2: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 106,629,578–106,629,705, 128 basesExon 2: 106,640,349–106,640,508, 160 basesExon 3: 106,640,823–106,640,921, 99 basesExon 4: 106,642,994–106,643,090, 97 basesExon 5: 106,649,025–106,649,201, 177 basesExon 6: 106,652,209–106,652,384, 176 basesExon 7: 106,652,467–106,652,582, 116 basesExon 8: 106,654,730–106,654,922, 193 basesExon 9: 106,655,615–106,655,732, 118 basesExon 10: 106,662,980–106,663,185, 206 basesExon 11: 106,665,782–106,668,417, 2,636 bases1246810115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 38.8 kb; 1,587 of those bases code for the protein.

Sequencing QRSL1

1Low

How hard QRSL1 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats4%
  • GC content3.5%
  • Reference coverage0%

3

positions in QRSL1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 38.8 kb of QRSL1, introns included, not only the 4.1 kb of exons.

Genes linked to the same conditions

Traits linked to QRSL1

The Human Phenotype Ontology lists these as features of the rare conditions QRSL1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). QRSL1 gene: glutaminyl-tRNA amidotransferase subunit QRSL1. Retrieved 17 October 2026, from https://dantelabs.com/genes/qrsl1

Vancouver

Dante Labs. QRSL1 gene: glutaminyl-tRNA amidotransferase subunit QRSL1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/qrsl1

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