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Gene

PLAG1

PLAG1 zinc finger

Summary

Cytogenetic location
8q12.1
Coordinates
Chromosome 8: 56,160,909–56,211,273 (GRCh38)
Exons
5 exons across 50.4 kb
Protein
500 amino acids
Also known as
ZNF912
MANE Select transcript
ENST00000316981.8NM_002655.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-Wiedemann

    • Silver-Russell syndrome

      A growth disorder, usually caused by methylation changes at 11p15 or maternal uniparental disomy of chromosome 7 and occasionally by variants in IGF2, PLAG1, HMGA2 or CDKN1C, that causes growth restriction before and after birth and body asymmetry.

      • 3 GenCC submitters rate it definitive or strong
      Actionability

      Diagnosis guides nutrition, blood-sugar and growth management.

How PLAG1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where PLAG1 sits. PLAG1 and 8 genes near it on chromosome 8, from 55,686,091 to 56,686,090.Chromosome 88q12.1p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.355.8 Mb56 Mb56.2 Mb56.4 Mb56.6 MbTMEM68: 55,696,424–55,773,417, reverse strandTMEM68TGS1: 55,773,065–55,827,247, forward strandTGS1LYN: 55,879,797–56,014,169, forward strandLYNRPS20: 56,020,034–56,074,575, reverse strandRPS20MOS: 56,112,942–56,113,982, reverse strandMOSPLAG1: 56,160,909–56,211,273, reverse strandPLAG1CHCHD7: 56,211,560–56,218,809, forward strandCHCHD7SDR16C5: 56,300,005–56,320,776, reverse strandSDR16C5PENK: 56,436,674–56,448,048, reverse strandPENKDiagram of PLAG1: 5 exons on the reverse strand of chromosome 8Exon 5: 5 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 56,160,909–56,167,503, 6,595 basesExon 4: 56,168,028–56,168,386, 359 basesExon 3: 56,171,091–56,171,189, 99 basesExon 2: 56,179,409–56,179,513, 105 basesExon 1: 56,211,121–56,211,273, 153 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.3 kb of the gene's 50.4 kb; 1,503 of those bases code for the protein.

Sequencing PLAG1

1Low

How hard PLAG1 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats4.8%
  • GC content4.8%
  • Reference coverage0%

6

positions in PLAG1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 50.4 kb of PLAG1, introns included, not only the 7.3 kb of exons.

Genes linked to the same conditions

Traits linked to PLAG1

The Human Phenotype Ontology lists these as features of the rare conditions PLAG1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). PLAG1 gene: PLAG1 zinc finger. Retrieved 17 October 2026, from https://dantelabs.com/genes/plag1

Vancouver

Dante Labs. PLAG1 gene: PLAG1 zinc finger [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/plag1

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