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Gene

NDUFA11

NADH:ubiquinone oxidoreductase subunit A11

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 5,894,675–5,903,790 (GRCh38)
Exons
4 exons across 9.1 kb
Protein
141 amino acids
Also known as
B14.7
MANE Select transcript
ENST00000308961.5NM_175614.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Primary Mitochondrial Disease

      • Mitochondrial Respiratory Chain Complex Deficiency

        One of 61 genes linked to it

        Isolated deficiencies of complex I, II, III, IV or V, caused by variants in nuclear or mitochondrial genes, which can affect the brain, muscles, heart, liver and other energy-demanding organs.

        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        Knowing can end a diagnostic search and guide surveillance of affected organs and avoidance of drugs toxic to mitochondria.

    How NDUFA11 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 19, with a bracket where NDUFA11 sits. NDUFA11 and 29 genes near it on chromosome 19, from 5,399,233 to 6,399,232.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.435.4 Mb5.6 Mb5.8 Mb6 Mb6.2 MbZNRF4: 5,455,417–5,456,856, forward strandZNRF4TINCR: 5,552,723–5,578,349, reverse strandTINCRSAFB2: 5,586,981–5,624,046, reverse strandSAFB2SAFB: 5,622,963–5,668,478, forward strandSAFBRPL36: 5,674,947–5,691,881, forward strandRPL36MICOS13: 5,678,414–5,680,940, reverse strandMICOS13HSD11B1L: 5,680,604–5,688,524, forward strandHSD11B1LLONP1: 5,691,834–5,720,572, reverse strandLONP1CATSPERD: 5,720,637–5,778,734, forward strandCATSPERDPRR22: 5,782,960–5,784,752, reverse strandPRR22: 5,784,005–5,785,619, reverse strandDUS3L: 5,784,832–5,791,225, reverse strandDUS3LNRTN: 5,805,053–5,828,324, forward strandNRTNFUT6: 5,830,361–5,839,722, reverse strandFUT6FUT3: 5,842,257–5,851,535, reverse strandFUT3FUT5: 5,865,826–5,870,540, reverse strandFUT5: 5,866,171–5,903,787, reverse strandNDUFA11: 5,894,675–5,903,790, reverse strandNDUFA11VMAC: 5,904,723–5,910,853, forward strandVMAC: 5,904,841–5,914,707, forward strandCAPS: 5,912,339–5,916,211, forward strandRANBP3: 5,916,138–5,978,288, reverse strandRFX2: 5,993,164–6,199,572, reverse strandRFX2ACSBG2: 6,135,247–6,193,094, forward strandACSBG2MLLT1: 6,210,377–6,280,029, reverse strandMLLT1ACER1: 6,306,030–6,333,612, reverse strandACER1CLPP: 6,361,427–6,370,242, forward strandCLPPALKBH7: 6,372,715–6,377,261, forward strandALKBH7PSPN: 6,375,148–6,379,058, reverse strandPSPNGTF2F1: 6,379,545–6,393,981, reverse strandGTF2F1Diagram of NDUFA11: 4 exons on the reverse strand of chromosome 19Exon 4: 5,894,675–5,894,854, 180 basesExon 3: 5,896,453–5,896,575, 123 basesExon 2: 5,896,905–5,896,997, 93 basesExon 1: 5,903,612–5,903,790, 179 bases43215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 0.6 kb of the gene's 9.1 kb; 426 of those bases code for the protein.

    How a genome test reads NDUFA11

    1

    position in NDUFA11 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 9.1 kb of NDUFA11, introns included, not only the 0.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). NDUFA11 gene: NADH:ubiquinone oxidoreductase subunit A11. Retrieved 17 October 2026, from https://dantelabs.com/genes/ndufa11

    Vancouver

    Dante Labs. NDUFA11 gene: NADH:ubiquinone oxidoreductase subunit A11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ndufa11

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